Frydman Lab @FrydmanLab
A lab at Stanford University studying protein biogenesis, folding, and aggregation in health and disease. Tweets by lab members. web.stanford.edu/group/frydman/… Stanford, CA Joined February 2020-
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Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab biorxiv.org/content/10.110…
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New exciting work from Jae Ho Lee in our lab, in a fantastic collaboration with Alessandro Ori @AOri_lab and Alessandro Cellerino @Alessan82703458 on why and how the brain ages and becomes vulnerable to neurodegenerative diseases science.org/doi/10.1126/sc…
Frydman Lab retweeted
Paging @NIHDirector_Jay . Is abruptly cutting these grants going to "make America healthy again"?
My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15
Frydman Lab retweeted
Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k
Frydman Lab retweeted
I stand with dozens of other biopharma leaders highlighting the potential catastrophic effects of proposed research cuts on bringing innovation to patients! statnews.com/2025/06/27/bio…
Frydman Lab retweeted
My NIDA grant renewal is almost 2 months late and I’m going to have to start firing my students and staff. Not a lot of transformation to be had in my lab.
Frydman Lab retweeted
Our lab at the Weizmann Institute was hit tonight by Iran We will rebuild and return 💪
@JSheltzer Such great news! Looking forward to many opportunities to collaborate and discuss science looking
@SergioCruzLeon1 @jpkreysing @MarinaLusic @Beck_Laboratory @MPIbp This is incredible! So incredibly cool and important. Congratulations!
@SamantLab Congratulations! Being a fellow Luddite myself I commiserate, but don't miss the irony I do so on social media. Looking forward to many more PhD thesis to come from your lab!
Frydman Lab retweeted
It was a pleasure to participate in the "Protein folding & Chaperones" platform session this morning in #bps2025 sharing our story from the @FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding
Frydman Lab retweeted
Closing an unforgettable chapter at Stanford. Grateful for the science, the growth, and the incredible people who shaped this journey—especially Judith, with whom I had the privilege of doing great science. This place and its people will always mean a lot to me. Very excited!
@nmr900 @LEK_Lab @UofT @EASorg December 4 Webinar | 10 a.m. - Noon EDT via @ProteinSociety mailchi.mp/proteinsociety… Congratulations on this super deserved award!
@HuaipengXing @Beck_Laboratory @goetheuni Congrats Dr Xing! A brilliant future awaits!
3) Two surprises that could only be revealed by cryoET raise new cool future questions (I) It uncovered a new cofactor, PDCD5 which binds to ALL open TRiC complexes (and was missed by biochemical studies) and (II) closed TRiC forms stereotypic clusters of mysterious function.
2) The MS also quantified TRiC-Prefoldin cooperation in vivo. Importantly it establishes that closed TRiC engages in specific interactions with quasi-folded substrate folding intermediates in its closed folding chamber, which is clearly NOT an "Anfinsen cage"
Check out our MS describing the in vivo cycle of chaperonin TRiC/CCT, in a wonderful collaboration with Martin Beck's lab: nature.com/articles/s4158… 1) The study established TRiC's important function in folding newly translated proteins and defines its ATP-driven cycle
@Beck_Laboratory @HuaipengXing @Nature Congratulations Huaipeng and Martin for this super-exciting collaboration and to all of the Beck lab for the warm welcome and hospitality during my sabbatical in Frankfurt last year! Not every day one discovers a new major chaperone cofactor, and from cryoET density no less.
A really nice piece on our recent study: med.stanford.edu/news/all-news/…
@CAMBUpenn @ErikaHolzbaur what a great paper!
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