Jonathan Weissman's Lab @JswLab
Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members. weissman.wi.mit.edu Cambridge, MA Joined October 2019-
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We’re hiring a Technical Assistant I/II in the Weissman Lab @WhiteheadInst to work on in vivo functional genomics with multimodal readouts. Our technicians have had incredible success going on to PhD & MD/PhD programs. Apply or send great candidates our way!
Excited to share our new preprint led by @YiChenNeumann with incredible collaborators @labs_mann, @BenGewurz, @StephenE92884, and @hopfnerlab to characterize the function of thousands of viral microproteins from human-infecting viruses! biorxiv.org/content/10.648…
Excited to share my PhD work, now on @biorxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer. biorxiv.org/content/10.648…
Jonathan Weissman's Lab retweeted
Excited to share my PhD work, now on @biorxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer. biorxiv.org/content/10.648…
Impressive work from @JShendure & co. reconstructing an E13.5 lineage tree with DNA Typewriter. A great complement to our PEtracer lineage atlas spanning E7.5-E10.0 (mela.wi.mit.edu). Excited to see what an integrated analysis of these datasets reveals!
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
Exciting work led by @AniaPuszynska !
Excited to see our work now published science.org/doi/10.1126/sc…! Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and
Jonathan Weissman's Lab retweeted
📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 biorxiv.org/content/10.648…
Jonathan Weissman's Lab retweeted
What is the global structure of cell-state space—and how do perturbations drive transitions within it? Excited to share our new preprint (biorxiv.org/content/10.648…), a work in collaboration with @JswLab.
Jonathan Weissman's Lab retweeted
A few years in the making in the @JswLab with @WilliamNColgan, Zack Smith, and the rest of our fantastic team: Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis. Excited to hear everyone's thoughts!
Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! biorxiv.org/content/10.648…
Special thank you to @WhiteheadInst @broadinstitute @kochinstitute @hhmi_science @czi @NIH
This has been a wonderful collaboration between our group and Zachary Smith’s Group @YaleMed and the Max Planck Institute with important contributions from @nir_yosef1 @WeizmannScience, @ZhuangLab @HarvardCCB, and Kyle Loh @Stanford
Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! biorxiv.org/content/10.648…
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