James Olzmann @OlzmannLab
Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology olzmannlab.com Berkeley, California. USA. Joined August 2018-
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Fantastic visit and seminar by Heather @ChristofkLab to our #MolecularTherapeutics series @berkeleyMCB. Heather’s work is truly unique in connecting fundamental metabolic insights to translation & therapy!
Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again rdcu.be/EbdVwEStSHha
Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! nature.com/articles/s4146…
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s4225…
In the latest issue! Metabolite buffering of labile iron governs ferroptosis dlvr.it/TVK0lZ
Excited to see our Preview led by Amalia Megarioti online in Cell, highlighting new work showing that polyamines act as endogenous buffers of labile iron to suppress ferroptosis. Congrats to Pushkal Sharma, Whitney Henry, Ankur Jain and team!👏 cell.com/cell/fulltext/…
UC BerkeleyのJames Olzmann教授 @OlzmannLab がサバティカルを利用して4ヶ月間 東北大学医学部に滞在されます。 Olzmann教授はフェロトーシスや脂質バイオロジーの専門家で、この滞在を利用して日本国内の研究者とも共同研究やdisucssionをさらに進められる予定です
@EMishima_lab Thank you, @EMishima_lab, for helping to host my visit at Tohoku University! I am already learning a lot and really enjoying my time here. Looking forward to many more discussions over the coming months with you and the research community!
My group in Discovery Oncology at @genentech uses machine learning to design new ways to target previously "undruggable" cancer-causing proteins. Go #InTheLab with me to learn more about connecting Oncology and AI-- linkedin.com/posts/genentec…
Excited to share our latest preprint led by Taylor Nuttall, in collaboration with @GileadSciences ! We identify a stereoselective covalent small molecule targeting the “undruggable” ovarian cancer transcription factor PAX8. KL6-159A covalently engages PAX8 C57, destabilizes PAX8, and suppresses its oncogenic transcriptional program, with FOXM1 emerging as the most strongly suppressed regulatory network. Another example of how reactive amino acid hotspots can provide unexpected footholds for directly drugging historically intractable transcription factors. biorxiv.org/content/10.648… #Chemoproteomics #ChemicalBiology #DrugDiscovery #PAX8 #OvarianCancer biorxiv.org/content/10.648…
📢 We’re hiring! The Stanford Chemistry Department is now actively conducting faculty searches (open area) - term to start on 9/1/2027: - Assistant Professor in Chemistry - Senior Faculty Position in Chemistry (Associate Professor or Professor) Learn more: chemistry.stanford.edu/news/hiring-ch…
MCB is hiring Assistant Professors across 3 divisions!: 🧪 BBS: aprecruit.berkeley.edu/JPF05483 🧬GGED: aprecruit.berkeley.edu/JPF05481 🦠IMM: aprecruit.berkeley.edu/JPF05486 🗓️ Application Deadline: October 19, 2026 🔗 Click the links or scan the QR codes to learn more and apply
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9zv3rjlj…
Thrilled to share our new work, co-developed w/Adrian Salic's lab: #bioorthogonal probes for PE, a multifunctional membrane lipid and source of several protein modifications. Congrats to @YuanTingCho1, @BrittMW08 , Jade Xia & Cindy Jao! onlinelibrary.wiley.com/doi/10.1002/an… #lipidtime
I'm glad to share the publication of new work carried from my postdoc with @weaverbird45 to my new laboratory @sbpdiscovery! Major implications for the relationship between immune oncology and metabolic syndrome. I'm deeply grateful to my co-authors! science.org/doi/10.1126/sc…
@Derpology @gtimblin @weaverbird45 @sbpdiscovery Congrats!! 👏
A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response. biorxiv.org/content/10.648…
Thrilled to share our new paper in Nature Chemical Biology led by Xiaoding Jiang. We developed XJ-4-85, a covalent PFKL activator that delivers a CPT2-targeting payload and suppresses tumor growth in vivo. Thanks to the Cambronne, Webb, and Kollman labs! doi.org/10.1038/s41589…
I am grateful for this recognition, which I owe to the phenomenal mentees who have graced our lab over the years, and to fantastic collaborators. I feel very fortunate to have worked alongside them, and I'm excited to keep exploring the mysteries of the cell in the years to come!
Congrats to MCB's Dan Fletcher & Roberto Zoncu on being named 2026 ASCB Fellows! 👏🎉 @ASCBiology @RobertoZoncu
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