Rahul Samant @SamantLab
Group Leader @BabrahamInst. He/him. All things #ubiquitin #proteostasis #proteomics #ageing #senescence. Spend too much on food & wine. Opinions mine, all mine! samantlab.github.io Cambridge, UK Joined March 2012-
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Rahul Samant retweeted
Hey @americanaging, something for your ECR members? jobs.ac.uk/job/DSV867/mar…
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Rahul Samant retweeted
Multi-organelle signatures map cell-state diversity and metabolic adaptation in tissues | Science science.org/doi/10.1126/sc…
Rahul Samant retweeted
A microprotein atlas of the human frontal cortex in Alzheimer’s disease nature.com/articles/s4358…
Rahul Samant retweeted
Reimagining research papers as interactive and reliable AI agents nature.com/articles/s4158…
Rahul Samant retweeted
Turning CDK4/6 inhibitors against the dark side of senescence nature.com/articles/s4358…
Rahul Samant retweeted
リソソームの機能低下は老化を能動的に駆動する原因の一つであり、有望な創薬標的になりうる リソソームは細胞内の不要物を分解する細胞小器官であるが、加齢とともに生合成の低下、酸性度の低下、分解活性の低下、膜の損傷といった機能低下が生じることが明らかになってきた。リソソーム機能低下と老化・疾患との因果関係の解明、そして安全にリソソーム機能を回復させる治療法の確立が、依然として課題として残されている。 本レビューはリソソームの生合成と品質管理の分子機構を整理した上で、その機能低下が慢性炎症や細胞老化、さらには神経変性疾患・代謝疾患・感染症への脆弱性の増加にどのようにつながるかを論じ、リソソームを標的とした治療戦略の可能性を検討している。 具体的な治療戦略としては、軽度のリソソームストレスがかえって適応的な機能亢進を誘導する「リソホルメシス」という概念、転写因子TFEB/TFE3によるリソソーム生合成プログラムの活性化、そしてESCRT複合体を介した膜損傷修復機構の強化などが論じられている。 老化の「隠れたハブ」としてのリソソームの重要性を改めて示した本レビューは、今後の創薬標的としての注目を高めるものである。 nature.com/articles/s4155…
Rahul Samant retweeted
Version of record. Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum | PNAS pnas.org/doi/10.1073/pn…
Rahul Samant retweeted
#Postdoc position available in my lab to study the role of senescence and senescence evasion in cancer therapy responses (available for up to 5 years) Check out saurinlab.com further details about project and lab culture in general. jobs.ac.uk/job/DSS226/pos…
Rahul Samant retweeted
We are hiring! 🌟 Dept of Biochemistry and Molecular Biology at the University of Chicago is searching for a tenure-track assistant professor. It's a broad search: we want great colleagues doing serious biological work at the molecular scale. Please share! apply.interfolio.com/191981
Rahul Samant retweeted
IMP postdoc Elias Adriaenssens has received an ERC Starting Grant worth close to €1.5 million. He will study how cells decide when to dispose of their organelles—and how they prevent healthy ones from being destroyed: bit.ly/4zUBQMy
Rahul Samant retweeted
Now online! Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types dlvr.it/TVJ3yK
Rahul Samant retweeted
Excited to share our paper on identification of secreted proteins during aging! Using proximity labeling and mass spectrometry, we identify secreted proteins that change during aging in C. elegans! Congrats to Jason Miklas and all collaborators! @JayJWM50 cell.com/cell-reports/f…
Rahul Samant retweeted
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter nature.com/articles/s4358…
Rahul Samant retweeted
After a while not posting, happy to share our latest paper on how the different J-domains interact with the various HSP70s! Proud of Roni and of the outcome🏆 @PNASNews pnas.org/doi/10.1073/pn…
Rahul Samant retweeted
Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice @Marc_dema nature.com/articles/s4358…
Rahul Samant retweeted
A new method for tracking protein-protein interactions in real time in living cells could open unexplored possibilities for understanding how cellular processes change with age. (1/9)
Rahul Samant retweeted
The @BuckInstitute is proud to sponsor the Livelong Women's Health Summit in NYC. Join leading experts, researchers, clinicians, and advocates for conversations about the future of women's health and longevity. livelongwoman.com #livebetterlonger @Livelong_Media
Rahul Samant retweeted
Now online! Polyamines buffer labile iron to suppress ferroptosis dlvr.it/TV1T1j
Rahul Samant retweeted
Delighted to share our paper in @FEBSJournal establishing a live-cell platform for resolving autophagy dynamics in naked mole-rat cells. This work was led by our amazing MPhil student, Fangze Tong. @psalmotoxin @UnivCamPharm doi.org/10.1111/febs.7…
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72 Followers 98 Following Tenure-Track Fellow at the University of Liverpool. Interested in endosomal biology and neurodegeneration.
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