Lyssiotis Lab @LyssiotisLab
Cancer and Immune Metabolism Research Laboratory @UMRogelCancer, @UMPhysiology, @UMICHpancreas lyssiotislab.com University of Michigan Joined November 2015-
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@apoptosislab They’ve got a bot running their Twitter. Not the first time a correction has triggered a “New!” 🙄😆
“The greater danger is allowing uncertainty to convince us to stop building, mentoring, investing in ambitious ideas, supporting vulnerable communities, or imagining a future worth creating until conditions improve.” #ScienceWorkingLife scim.ag/4dxT88v
This month, a Michigan woman used a brain-computer interface (BCI) to speak with @matthew_willsey, the neurosurgeon who implanted the device in June at @umichmedicine, as part of a team from the Department of Neurosurgery. nytimes.com/2026/09/14/wel…
Another step forward in targeting RAS. A new @NatureMedicine phase 1 study of GFH375/VS-7375, an oral drug designed specifically for KRAS G12D, showed tumor shrinkage in about 1 in 3 heavily pretreated patients with pancreatic or lung cancer. In pancreatic cancer, median PFS was 5.5 months and median OS 9.9 months. About a third of patients had grade ≥3 treatment-related side effects. While the recently approved daraxonrasib targets multiple RAS mutations, this drug is selective for KRAS G12D. Still early, but another encouraging approach against a historically difficult target.
Cysteine excess triggers a mitochondrial iron-dependent cell death dlvr.it/TVV53x
Excited to see our work published in @ScienceAdvances! 🎉 Very grateful to Gina DeNicola (@LabDeNicola) and all our coauthors who made this work possible. 🔗 science.org/doi/10.1126/sc…
Cancer and metabolism articles, August 2026 As always, you can receive the MetaboList by email by registering through the main page
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s4225…
Love this from @LyssiotisLab, @BrandonTWChen & @YatrikShahLab! 🔥 Check it out 👇 sciencedirect.com/science/articl… And if anyone wants to isolate ER–mitochondria contact sites… SPLICS might come in handy 😉🔬
Lactate is toxic. Lactate causes fatigue. High lactate is bad. We hear some version of this all the time. But how much of it is actually true? So we wrote a review separating what we know about lactate from what we’ve simply assumed for decades. Led by our fantastic postdoc Bhavya Blaze! @Bhavya391554759 onlinelibrary.wiley.com/doi/10.1002/bi… #Lactate #Metabolism #ScienceTwitter
MIT published a brutally honest report on what AI is doing to students. A committee of professors and students spent five months studying how AI changed learning on campus, and the findings read like a warning to every university on the planet. Study groups are disappearing. Office hours are emptying out. Problem sets and take-home exams no longer prove anything, because AI can produce credible solutions to almost any written assignment in the undergraduate curriculum. Students who lean on chatbots lose mastery and confidence, and some slip into what the report calls cognitive surrender, reaching for AI at the first hint of struggle. The numbers are rough. 46 percent of surveyed MIT undergrads use LLMs daily. 90 percent worry about their own overreliance. Undergrads who feel AI makes them replaceable now outnumber those who feel it makes them capable. The committee's answer surprised me. They refused to fight AI with surveillance. The report calls AI detectors unreliable, says lockdown browsers feel like spying, and warns that policing students builds a classroom atmosphere of mutual distrust. Instead, MIT wants to rebuild education around the things AI can't replace. That means oral exams, semester portfolios, in-person project work, and a required social component in every subject. The report even floats the idea of rethinking grades entirely, since without a GPA to optimize, much of the incentive to cheat with AI evaporates. The committee warns professors against replacing undergrad research assistants with AI agents just because they're cheaper, because a university exists to grow people, not output. The most famous tech school on earth admitted the machines broke its way of teaching. Its answer is more humans, not more software.
Our preprint is now published: In collab. w/ Ruma Banerjee we show how the B12 chaperone MMADHC spends its life in two cellular 'zip codes' dictated by the mitochondrial PMF (similar to PINK1). Co-led by @Sneha_Rath_, Zhu Li. doi.org/10.1073/pnas.2…
Excited to share new work in collaboration w/ Ruma Banerjee’s group. Following mitochondrial depolarization, the vitamin B12 chaperone MMADHC is stabilized and boosts B12-dependent MTR activity in the cytosol. Regulation is reminiscent of PINK1, ATFS1. biorxiv.org/content/10.648…
Very excited to share our new paper, published in Cell! We found that caloric restriction (CR) in mice reduces somatic mutation burdens across the genome, and that this effect has some surprising features. 🧵👇 1/8
Pancreatic tumors are highly heterogeneous and immunosuppressive. But is immune resistance imposed across the whole tumor - or built locally by distinct cancer-cell states? I’m incredibly excited to share our new paper, now out in @Nature! 🎉 doi.org/10.1038/s41586… (1/7)
They explored long term effects of sugar rationing in the UK in 1953 - how cool Early-life sugar restriction causally reduces adult cancer incidence and slows biological aging | PNAS pnas.org/doi/10.1073/pn…
Yesterday was a glorious day of science @nyugrossman @nyulangone with two fantastic papers 1st by @giladevrony on impact of caloric restriction on mutation rates: cell.com/cell/fulltext/… 2nd by @MarcusDGon @eze_dantas on refined starches & immune markers cell.com/cell-press-blu…
Read the backstory behind the phase I GlutaPanc trial in this @NatureCancer #ResearchBriefing, including challenges in funding this unconventional therapy in #PDAC when glutamine deprivation, not supplementation, was the historical approach nature.com/articles/s4301… @OncoAlert
The @UM_MNI has opened a tenure track faculty search for neuroscientists. The MNI is a cross campus institute and candidates will join a department on campus including @UMPhysiology. We hope to recruit a great new neuroscience colleague in MIP! apply.interfolio.com/192977
Congratulations to Dave Tuveson, the new Director of @DukeCancer. What a massive coup for @DukeMedSchool. medschool.duke.edu/news/david-tuv…
A friend pointed out this new RPMI cell culture media from Sigma that lacks leucine, arginine, and lysine (-LRK). This is exactly the media we would make in house to study amino acid sensing by mTORC1 so should be useful to many: sigmaaldrich.com/US/en/product/…
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