Noble Kumar @nobletalari
PostDoctoral Fellow, Investigating the role of mitochondria in NAFLD and metabolic syndrome Cincinnati, OH Joined January 2022-
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@UCPPNDept @UCincyMedicine @GradCollegeUC Congratulations Georgios
As I’ve said multiple times , postdoc is the worst job you can have with a PhD in these times. I try hard to soften this blow for anyone in my lab and it barely scratches the surface..
Postdoc time is often harder than PhD. You have little time. Competition is higher. And you MUST stand out. + Your contract may end any moment. + Your salary is often low (for your age/education). + You’ve just relocated and prepare to relocate again. No wonder that Max
@cohenlaboratory @ChihHsuanHsu1 @UNC_SOM Congratulations
@OlzmannLab @ASBMB Congratulations James Olzmann.
Excited to share equal first author paper published in @JMCCardiology Full article link: jmcc-online.com/article/S0022-… Huge thanks to @KarthicK_PhD , @MattamUsho14047 and @kdrosato
6/ Huge thanks to the amazing team @nobletalari, @MattamUsho14047, Afra, Brook & collaborators! @UCPPNDept @UCincyMedicine @UCResearch @UCCOM_undergrad Read the full story: nature.com/articles/s4200… #OpenAccess #ScienceTwitter #MASH #LiverResearch
5/ Why this matters: Understanding these mitochondrial dynamics offers new insights into how hepatic energy metabolism adapts (or maladapts) in MASH. Could this open doors to novel therapeutic strategies?
4/ Morphological changes: Early MASH: PDMs became larger & more elongated. Advanced MASH: CMs became smaller & fragmented. 👉 This compartmentalization hints at mitochondrial specialization during metabolic stress.
3/ Key findings: PDMs = bioenergetic powerhouses, with higher pyruvate oxidation, TCA flux & oxidative phosphorylation protein complexes. CMs = shifted towards fatty acid oxidation, reflecting metabolic adaptation. Distinct mitochondrial functions drive MASH progression!
2/ What did we investigate? We examined cytoplasmic mitochondria (CM) and peridroplet mitochondria (PDM) in a diet-induced MASH mouse model. As MASH progressed, we observed an inverse relationship between these two mitochondrial populations!
1/ New paper alert! Excited to share our latest work on hepatic mitochondrial subpopulations and their distinct roles in MASH progression! 👉 Read here: nature.com/articles/s4200… #LiverResearch #Mitochondria #Metabolism #MASH #MASLD
we characterized the importance of hepatic PDM and CM, found that their content, dynamics, and bioenergetic capacities differentially altered from steatosis to fibrosis progression. Huge thanks to @MattamUsho14047, our PI @KarthicK_PhD and the entire K lab team
Excited to see my another first author publication on hepatic mitochondrial subpopulations (Peridroplet mitochondria (PDM) and Cytoplasmic mitochondria (CM) @commBio. rdcu.be/eaoRj
@Mottillo_Lab Congratulations Emilio Mottillo
The K lab had an amazing time at the 38th Annual Meeting of the Ohio Physiological Society (OPS)! 🎉 We presented posters and delivered oral talks. Huge congrats to @nobletalari for securing one of the top 5 Blitz Talk awards! 🏆
One of the most important issues of our time - particularly critical in the US
So excited to announce the publication of our research in @iScience_CP. Kudos to our postdocs, Noble Kumar Talari and Ushodaya Mattam, and our undergrads, Irene Sotomayor-Rodriguez and Afra Rahman. @UCPharmSysPhys @UCincyMedicine @MedSciMenon cell.com/iscience/fullt…
It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size. life-science-alliance.org/content/7/2/e2…
@KarthicK_PhD @nih_nhlbi @UCPharmSysPhys @UCincyMedicine @UCResearch Congratulations Karthick…
Happy to share our paper out in @NatureComms, in which we developed a method to isolate lipid droplet associated mitochondria from liver and showed it is bioenergetically different from cytosolic mitochondria population nature.com/articles/s4146…
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