YouleLab @LabYoule
Youle Lab members. Mitophagy, mitochondrial quality control and autophagy lab. Molecular mechanisms underlying early onset Parkinson's disease. Bethesda,MD Joined June 2020-
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Exciting mitochondria news! Check out the new preprint by @PoratShliomLab group, led by @SunWooSophieKa1 with assistance from @RoryCunningham, Colin Miller, Conny Cultraro. Discover how they studied the functional diversity of hepatic mitochondria using Intravital Microscopy:
Our new preprint, “A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling” is now online! Led by the talented @SunWooSophieKa1 with help from @RoryCunningham, Colin Miller Conny Cultraro
Next Thursday February 9th, Dr. Richard Youle (@youle_rj ) will be talking about the work that has been done in our lab on #mitochondria quality control at the Aging Institute-University of Pittsburgh @AgingPitt (zoom link💻/location in the image from the original tweet)
@slavov_n Pink1 is another example of a protein constitutively translated only to be degraded. Upon import impairment of an individual mitochondrion Pink1 proteolysis is prevented allowing it to accumulate on that mitochondrion to recruit Parkin and initiate mitophagy.
Found a spooky #bacteria #ghost transformation in the Lab!!! @LabYoule #GlowintheDark #halloween2021 #GFP #ScienceIsFun 👻🎃💀
The VPS13 proteins are thought to mediate #lipid transport between organelles & are linked to distinct neurological disorders. Baldwin, @LabYoule et al. find that, in addition to mitochondrial morphology, VPS13D is essential for peroxisome biogenesis. bit.ly/3sMSxpq
and don't forget to read also the amazing paper by @AGuillenSaman @PDClab doi.org/10.1083/jcb.20… where they show that Miro recruits VPS13D to mitochondria and peroxisomes!
Very excited to share our latest work on VPS13D. In this paper we describe that VPS13D is not only required for #mitochondria morphology; but also, to regulate proper #peroxisome biogenesis. Congrats Heather Baldwin, Chunxin Wang, @gil_kanfer @youle_rj and collabs🥳#ataxia #vps13
The VPS13 proteins are thought to mediate #lipid transport between organelles & are linked to distinct neurological disorders. Baldwin, @LabYoule et al. find that, in addition to mitochondrial morphology, VPS13D is essential for peroxisome biogenesis. bit.ly/3sMSxpq
Very happy to share with you the recent news that Richard Youle was elected as a member of the American Academy of Arts and Sciences! @americanacad Congratulations @youle_rj !🥳
Congratulations to the newly elected members of the American Academy of Arts & Sciences! Today we are honored to welcome 252 scholars, leaders, artists, and innovators into the Academy. ow.ly/RPWa50Evk4D
📌Talk by Richard Youle @youle_rj @LabYoule 🗓️12th May 2021 - 1pm EDT REGISTER HERE: zoom.us/webinar/regist…
Want to understand how deficiencies on the ubiquitin-mediated protein quality control systems are associated to neurodegeneration? Read this insightful review by François Le Guerroué and @youle_rj! Still 6 days for free! rdcu.be/cfHZu #PD #Alzheimers #PD #ALS #PTD
Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. A novel pooled screening approach from Gil Kanfer (@gil_kanfer) Richard Youle (@youle_rj) and colleagues from @LabYoule @JLS_Lab: bit.ly/3bURzCz #autophagy #mitochondria #AI
Thrilled to share with you our latest publication led by @Gil_kanfer. Here we describe a novel image-based method to perform #CRISPRi screening to detect changes in subcellular phenotypes using high-content imaging and #MachineLearning. #autophagy #mitochondria #lysosomes #AI
In @JCellBiol: Combining high content imaging, machine learning and photoactivation, Kanfer et al have developed a novel image-based #CRISPRi method to screen subcellular phenotypes: bit.ly/3bURzCz @gil_kanfer @youel_rj @LabYoule @JLS_Lab @Lluniz #mitochondria #AI
Don't forget to follow Shireen Sarraf's presentation tomorrow: Loss of TAX1BP1-directed autophagy results in protein aggregate accumulation in the brain. 10:30am EST @WAutophagy 1st Annual Symposium #autophagy #neurodegeneration @LabYoule
Around 24 hours to start our First Annual Beth Levine's WIA symposium! Don't miss it!! #WIA #Autophagy
We invite you to watch @Jobby1kanobi presenting the work he developed @LabYoule on how the #autophagy receptor NDP52 and TBK1 mediate ULK1 recruitment and activation during #mitophagy @AIM_autophagy Early Career Investigator Series autophagy.center/super/videos/8…
It's publication time at the lab! We are excited to share @asdfTARAghjkl report in collab with M. Lazaraou´s lab describing that ATG16L1 is required for V-ATPase-mediated LC3B lipidation on single membranes upon the activation of the innate #immune receptor STING #autophagy
Tara Fischer, Richard Youle @NINDSnews and colleagues show cGAMP activated STING induces V-ATPase recruitment of ATG16L1 for LC3B lipidation onto single membrane perinuclear vesicles. bit.ly/2IIlP7i #Celldeath #autophagy #immunology
Protein aggregation is a pathological hallmark of #neurodegeneration, so we are very proud to announce our latest publication led by Shireen Sarraf in which she described the role of the #autophagy receptor #TAX1BP1 on the clearance of protein aggregates #ALS #HD @NINDSnews
Online Now: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain dlvr.it/RltR0n
Looking to leverage existing systems to clear out protein aggregates to tackle neurodegenerative diseases such as #ALS #MND? @MolecularCell Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain bit.ly/32TWbUq @LabYoule
Happy to share with you this interesting review on the relationship between mitochondria quality control mechanismsb and immunity from @atmoehlman @youle_rj @LabYoule annualreviews.org/doi/10.1146/an…
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