KeyserLab @KeyserLab
We are a group of scientists at the Cavendish Lab, University of Cambridge, UK. Focused on understanding transport processes through membranes. keyserlab.org Cambridge, England Joined July 2019-
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KeyserLab retweeted
(1/n) How do we detect modified RNA, and DNA with the help of template-free, catalyst-free click chemistry and solid-state nanopores? 🧪🥼🧬🕳️
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KeyserLab retweeted
Leveraging rRNA's 100,000-fold higher abundance over rDNA, we developed a one-pot method for RNA isolation, enrichment, and assembly of RNA identifiers, enabling detection of pathogenic bacteria and AMR variants without the need for amplification! 🧬🥼 @sarahesandler @KeyserLab
KeyserLab retweeted
pre-print alert!🚨 @FilipBoskovic12 and I’s collaboration from our time in the @KeyserLab using #nanopores for serovar discrimination with single base pair specificity of rRNA is now on biorxiv! 🦠 biorxiv.org/content/10.110…
In a study led by @FilipBoskovic12 we examined how the electrophoretic transport of RNA:DNA and DNA through nanopores depends on the contour length rather than the number of base pairs. Nice blend of experiments and simulations! @aksimentievLab @acsnano 🧬🕳️⚛️ @Cambridge_Uni
_1/n Honestly, it has been an incredible experience to scratch the surface of the physics behind our applied work! Building on the work of nanopore crew, we've uncovered some unexpected clues about the electrophoretic translocation of duplexes and how their form affects velocity!
🥳 New paper from the group! @casey_platnich has shown with nanopore sensing that the denaturing properties of urea can be used to break up RNA secondary structure and allow DNA staples to bind without heating! 🧬 Check out the paper in @J_A_C_S here:tinyurl.com/5bkx7nzv
KeyserLab retweeted
Great second session at @CamInfectDis Annual #Symposium @ksbakes @KeyserLab @Chris3Ruis @monkeymyshkin @RobinsonCamb
KeyserLab retweeted
Check out our new article in @NatureComms ! We use RNA nanotechnology and nanopore sensing to assess transcript size and heterogeneity. We identify premature transcription termination, study rolling circle transcription and describe enzymatic processivity. Special thanks to everyone at @KeyserLab, @FilipBoskovic12 and our great collaborators @fondzanauku_rs. 🧬 nature.com/articles/s4146…
KeyserLab retweeted
Our latest paper collab with lots of great colleagues is now available in @an_chem, extending our solid-state #nanopore approach to analyzing the size distribution of heavy-chain modified #hyaluronan from physiological biofluids. pubs.acs.org/doi/full/10.10…
KeyserLab retweeted
While characterising harmful oligomers is crucial to developing accurate diagnoses and treatments for diseases involving misfolded proteins, like Alzheimer's, identifying them in complex mixtures has remained challenging. This new test may change that. chemistryworld.com/news/nanopore-…
KeyserLab retweeted
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores | Journal of the American Chemical Society @Cambridge_Uni @DeptofPhysics @Maxwell_Centre #digital #Characterization #Misfolded #Protein #Nanopores pubs.acs.org/doi/10.1021/ja…
KeyserLab retweeted
Our paper is finally out in JACS! Exciting to see this collaboration (@KeyserLab,@VendruscoloLab) develop into a project with a lot of potential impact in both the fields of #protein #sensing using #nanopores and PD #diagnostics and #therapeutics 🧬💊 pubs.acs.org/doi/full/10.10…
KeyserLab retweeted
With Uli Keyser you always get the combination of cool physics and application driven assay development.
KeyserLab retweeted
Four of our physicists have been recognised in the @IOP Awards 2023 for their outstanding contribution to experimental physics, public engagement, soft matter physics, and atomic physics. Congratulations to them!🏅 Follow the thread to learn about the winners and their awards 🧵
KeyserLab retweeted
KeyserLab retweeted
In a paper in @NatureNano, researchers @Cambridge_Uni went fishing for viruses using programmable DNA nanobait technology. @KeyserLab bit.ly/3Zu7M8L
End-of-summer barbecue and foosball at Ulrich’s house 🍖 🌱 ⚽️ 🧬
KeyserLab retweeted
Check out my first first author paper of my PhD out now in @natBME ! We utilize solid state #nanopore sensing and #dna #nanotech as a way to assay #CRISPR #Cas9 binding efficiency!
Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores nature.com/articles/s4155…
KeyserLab retweeted
Latest review on nanopore protein sequencing, have a look!
I am glad to see a year of hard work with @XiaojunWei2 and @aksimentievLab getting published today on ACS Nano! This is an exciting field with great potentials and we learned a lot writing this review paper: pubs.acs.org/doi/full/10.10… @UofSC_CEC @USCResearch
KeyserLab retweeted
Check out our new paper in Nanoletters led by the talented Yunxuan Li, where we use DNA nanostructures and nanopore signals to characterize the physical properties of DNA! @NanoLetters @KeyserLab #dna #nanotech #nanopores pubs.acs.org/doi/10.1021/ac…
KeyserLab retweeted
Delighted to annouce our work is out @nanoscale_rsc! A big team effort @KeyserLab @group_laser @mng_ceb @David_Holcman @NathalieRouach Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiology pubs.rsc.org/en/content/art…
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