Gygi Lab @GygiLab
@harvardmed research group developing methods and tech in the fields of mass spectrometry and proteomics. Account managed by postdocs and student. gygi.hms.harvard.edu Harvard Medical School Joined October 2019-
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If you're going to #ASMS2025, don't miss these presentations from members of the Gygi lab! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging @HMSBioPlex for drug discovery, new instrumentation, and much more! @EdHuttlin @stshuken @AmandaLSmythers
I was quoted in this very well done story by @MaryKekatos at @ABC highlighting some of the grants that were tragically and needlessly terminated including mine. abcnews.go.com/US/350-harvard…
#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how @HMSBioPlex is enhancing drug discovery! @harvardmed @asmsnews
It’s also worth mentioning that the AP-MS data in this study was collected by the @HMSBioPlex team at @harvardmed.
In a Nature article researchers from HPA and UCLA have used a machine learning approach that enables computational integration of protein localization data from IF images and AP-MS protein interaction data to create a MuSIC map of 5,100 proteins in U2-OS. proteinatlas.org/news/2025-05-2…
Congratulations to all this year's @asmsnews award winners, including Gygi lab alumnus @qingyuhms!
It’s an incredible honor to receive the ASMS Research Award. I’m thankful to the selection committee and humbled to be alongside with so many brilliant scientists. This recognition is a reflection of the amazing collaborators and mentors I’ve had the privilege to work with.
Check out this paper to read how @HMSBioPlex interactions can be combined with @ProteinAtlas images to model the cell! Leah Schaffer, @Clarararara_hu @TreyIdeker @Prof_Lundberg @EdHuttlin
🚨 New in Nature @Nature! 🚨 Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐 📝 Paper: nature.com/articles/s4158… 🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/
Check out MuSIC 2.0, combining @ProteinAtlas images and @HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with @TreyIdeker, @Prof_Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & @Clarararara_hu!
🚨 New in Nature @Nature! 🚨 Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐 📝 Paper: nature.com/articles/s4158… 🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/
It's great to see lab alumnus Jose Navarrete-Perea featured in JASMS. While in the lab, Jose played a key role in our TMT and instrumentation work and was an essential part of our @HMSBioPlex project, and much more. Congratulations, Jose! @asmsnews pubs.acs.org/doi/10.1021/ja…
Congratulations to lead author Jamie Schneider, Gygi lab coauthors @BrandonGassaway and Joao Paulo, and all the other coauthors!
Check out the latest collaboration between the @haigislab and the @GygiLab which is out in @CellCellPress today! ALK fusion-driven phosphotyrosine signaling works through GUK1 to regulate GDP/GTP levels, which in turn attenuates GPCR signaling in NSCLC: sciencedirect.com/science/articl…
Collaborative efforts with @GygiLab, Hans Widlund, Kai Wucherpfennig Labs @DFCI_CancerBio @DanaFarber #HarvardCellBiology @bwhdermatology @harvardmed Be on the lookout for a 🧵by @TevisVitale for a more detailed explanation!
I’m so grateful to have worked with these wonderful people on this awesome paper that came out in Cell today! Linking ALK phosphotyrosine signaling through GUK1 to regulate GDP/GTP levels in cancer. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… @HaigisLab @GygiLab @CellCellPress
Happy birthday to Proteomics!
Proteomics Turns 30! It is thirty years since Prof. Marc Wilkins (then an early career researcher) introduced the term "proteomics" at the International Meeting on "2D Electrophoresis: From Protein Maps to Genomes" in Sienna (Italy). #proteomics
Congratulations to @stshuken on this impressive achievement!
I’m overjoyed to announce that my K99/R00 proposal has been funded by @NIHAging as of today!! I am very excited about the project which is a collaboration with @LehtinenLab to study the blood-CSF barrier with new analytical tools I’ve developed in the @GygiLab. Feeling grateful!!
Check out this blog post and paper from Alberto Cruz-Martín, @rhushikeshphadk, and colleagues describing how @HMSBioPlex helped them link the complement pathway to synaptic dysregulation! communities.springernature.com/posts/beyond-p… rdcu.be/dSTkf
My work with @qingyuhms on our new TMT-ABPP at @GygiLab is now available online. The new method incorporating streamlined sample prep, TMT multiplexing and FAIMS-hrMS2 allows you to analyze ~18k cysteines across 18 samples starting from 10 ug proteome! sciencedirect.com/science/articl…
Our multifaceted tool PISA-REX profiles the proteome of any given biosystem at the dimensions of protein solubility, expression and redox state, at high depth and throughput, for target deconvolution. Grateful to people at the @RZLabKI and the @GygiLab. onlinelibrary.wiley.com/doi/10.1002/ad…
Congratulations to lab alumnus @dschweppe1 on this well-deserved award!
Honored and excited to join (and meet) this cohort of the Pew Scholars with fellow UWer Claudia Vásquez! Many thanks to the hard work from the great group members here at @uwgenome & help along the way from mentors/colleagues: @GygiLab @GarciaLabMS @scottagerber @Bruce_Lab_UW
He's looking for some great people to join his lab, so if you're interested in (chemo)proteomics and mass spectrometry, be sure to take a look at his lab! Check out his lab website at yu-research.org and apply at ummsjobs.com/job/10402/.
Today we celebrated the end of an era as @qingyuhms wraps up several highly productive years in the lab! Though we'll miss him, we wish him the best as he starts his own group, and we're glad he'll still be nearby at @UMassChan.
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