ingenious targeting laboratory @GeneTargeting
Let’s explore new scientific possibilities together! At Ingenious, we’re passionate about advancing research through custom targeted mouse models. genetargeting.com Ronkonkoma, NY, USA Joined November 2010-
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Founder mice do not establish a line. The allele must transmit through the germline before breeding and cohort planning can begin. ingenious guarantees transmission. If it does not transmit, you are not charged. #MouseModelGeneration #GermlineTransmission #GeneTargeting
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New in J Exp Med: Wetterwald et al. link a MYCT1 and IFITM2/3 interaction to endothelial endolysosomal trafficking and white adipose expansion. iTL provided the mouse model. Findings are the authors'. Paper below. #Metabolism #VascularBiology #Adipose
If the floxed locus and the Cre insertion sit on the same chromosome, Mendelian ratios do not apply. You need a meiotic recombination event, and yields fall off a cliff. Check locus positions during design, not after weaning. #CreLox #MouseGenetics #ConditionalKnockout
Pups arriving across eight weeks is not a cohort. It is an uncontrolled age variable sitting inside your study group. Parallel pairs with staggered starts land the litters in one window. Ask us to size the scheme. #MouseModels #PreclinicalResearch #InVivo
Read this article here! FREE! hubs.la/Q04my6bN0
Great Read! hubs.la/Q04hXqQM0
14,774+ catalog mouse and rat models for study ready discovery. Faster access to established alleles on defined backgrounds, with custom development available when projects evolve beyond the catalog. hubs.la/Q04hknM_0
Full Gene Humanization Replace an entire mouse gene with its human ortholog, including introns, regulatory elements, and splice sites, in one step. #HumanizedMice #MouseModels #TranslationalResearch #PreclinicalResearch hubs.la/Q04gdvRP0
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