Tjakko van Ham @vanHam_lab

Associate prof, clin lab specialist, functional genomics & RNA diagnostics of genetic disease, zebrafish, glia, leukodystrophy erasmusmc.nl/en/research/gr… Rotterdam, Nederland Joined July 2012

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Wittamer Lab @ValerieWittamer

4 years ago

🚨Please RT🚨 We are hiring! We have two immediate #postdoc openings! If you are interested in studying #microglia #development and functions, and want to use a cool animal model, #Zebrafish, to do that, please apply! More info: wittamer-lab.org/opportunities

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Tjakko van Ham @vanHam_lab

4 years ago

Happy our paper on RNA-seq to diagnose rare genetic disorders is out in @AJHGNews with @GraziaMancini3 @Jordy_Dekker_ and others from @Erasmusgenetica! 🎉🎊

AJHG @AJHGNews

4 years ago

New! @Jordy_Dekker_ et al. provide a web-based tool to improve RNA-Seq-based analyses of neurodevelopmental disorders bit.ly/3D1TBxw

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Stefan Barakat @StefanBarakat

4 years ago

📣📢Hiring alert❗️ We are looking for a computational postdoc to join our team @Erasmusgenetica @ErasmusMC, working on the #noncoding genome & #epilepsy. Please RT! #ZonMw #Vidi #raredisease #generegulation #neurodevelopment #enhancer #teamsport #genetics bit.ly/3cJ537C

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Tjakko van Ham @vanHam_lab

4 years ago

@DePaterLab @ckoyunlar Congrats Emma and Cansu! 👏🎉🎉

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Tjakko van Ham @vanHam_lab

4 years ago

@NeuroNiko @wmberdowski @Lesliezfish Thanks Nick!

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Tjakko van Ham @vanHam_lab

4 years ago

Happy to announce a new paper from the lab! Very proud of this work by senior PhD candidate @wmberdowski (1st 1st author paper) others from the lab @Lesliezfish & collaborators not on twitter: link.springer.com/article/10.100… #ErasmusMC #zebrafish #glia #leukodystrophy #RareDisease 1/9

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Tjakko van Ham @vanHam_lab

4 years ago

@wmberdowski pursued this/other aspects further in the last 3 yrs, with great perseverance, and our conclusion is that it could be a compensatory astrocytic phenotype indeed. As always this also raises new questions (e.g. do abnormal astrocytes contribute to leukodystrophy?)

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Tjakko van Ham @vanHam_lab

4 years ago

We then asked the question: could we get a glimpse of what consequence is of lower microglia density? #multiomics Proteomics and RNA-seq data led to us to an abnormal endocytic astrocyte phenotype in #zebrafish and in #ALSP associated with lower microglia density. 5/9

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Tjakko van Ham @vanHam_lab

4 years ago

Having shown the loss of microglia in #ALSP, this supports the idea that stem cell transplantation could benefit ALSP patients (as shown in several small scale clinical studies) Thanks to all involved @Erasmusgenetica, and ActaNeuropath for constructive/efficient review! 9/9

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Tjakko van Ham @vanHam_lab

4 years ago

I was quite excited about the original findings, and applied to some grant to follow up on this (which I didn’t get 🙄). But continued the research regardless😛! Also see (in Dutch) amazingerasmusmc.com/brain/zebrafis… 8/9

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Tjakko van Ham @vanHam_lab

4 years ago

@rogiermin @Czopka_Lab @F_deVrij Indeed, thanks for initiating Rogier, fun to organize and to hear about novel white matter cell functions & tools to study them & clinical perspective!

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Tjakko van Ham @vanHam_lab

4 years ago

Nice indeed 👏and nice supporting role by #zebrafish genetic models @Jordy_Dekker_

Stefan Barakat @StefanBarakat

4 years ago

Nice talk by our colleague Daphne Smits from @GraziaMancini3 lab @Erasmusgenetica identifying CLEC16A as a New NDD gene #ESHG2022

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Tjakko van Ham @vanHam_lab

4 years ago

Awesome (virtual) chalk talk (no slides) by @OdedRechavi Question in Q & A "I can't see the slides" Oded: "there are no slides" 😀 #ESHG2022 #rnainheritance pic.x.com/Pn0oTL44uC

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Tjakko van Ham @vanHam_lab

4 years ago

Very nice/proud to see @Jordy_Dekker_ present this: rotated as 1st yr MSc in '15, came back after his MD for more and now close to get his PhD in lab cosupervised w/ @GraziaMancini3 and together w/Functional Genomics unit @Erasmusgenetica at #ESHG2022

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Tjakko van Ham @vanHam_lab

4 years ago

Presented @ #ESHG2022 by PhD student @Jordy_Dekker_ !

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Tjakko van Ham @vanHam_lab

4 years ago

Our new Preprint: lnkd.in/dWXmhEJk Finding a cause in rare genetic disorders is key for treatment/prognosis/counseling, but often this cause is hard to find in DNA. Diagnostic RNA-sequencing improves diagnosis for neurodevelopmental disorders medrxiv.org/content/10.110…