kat @katclone

@maggiezli I’d swap 2 and 3 😹😹😹

Biotech investors and tech investors could not be more different.

@Oliver__Hahn What’s more shocking is tech investors transitioning to more hard core bio in last few years!

@Oliver__Hahn lol it’s not shocking to me

Completely different archetypes and energy

you should start a biology research institution going after your own personal millennium problem. there has literally never been a better time

Have days where you binge meetings and then days when you’re on DND, easy

APAJI @apaji_x

a week ago

BREAKING: ADHD researchers confirm that having "one single appointment" at 3:00 PM successfully destroys the entire day leading up to it. 1/6

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Chicagoooooo: we’re back Creator Hackathon V3 is Sep 27, 11am–4 at @drivecapital We’re bringing together the top creators, founders, and builders in the city to build with AI the same day Marketing with @ElevenLabs, agents with @bot, and sites with Near AI Rooftop happy hour after with Banterr luma.com/creatorhackath…

@landon20s @drivecapital @ElevenLabs @bot 🔥🔥🔥🔥🔥 carrying the future of Chicago

UNC⁠ will establish the Initiative for Generative Immunotherapy, creating public, multimodal data, to help reach a future where cancer patients can get rapid personalized cancer vaccines when they are diagnosed. Today’s “neoantigen” cancer vaccines are one of the few medicines designed computationally for each patient, by sequencing a tumor cell to predict which tumor-specific targets are presented on its surface. But that sequencing is itself a proxy of reality, because it is difficult and expensive to measure the cell’s surface targets directly, and furthermore to check how strongly a patient’s immune system reacts to each of those proteins. UNC will generate those missing links across hundreds of tumors and multiple different types of cancer, creating one of the first training and evaluation datasets in this field, with de-identified public data for researchers around the world to build on. We're proud to support @iskander and @BenjaminGVincen as they build something big and new here: abc7news.com/post/openai-fo…

LFG, @iskander and @BenjaminGVincen are incredible, honored to have gotten to know them and their work in the last year+ Huge win for science!

alex rubinsteyn @iskander

2 weeks ago

Starting a new thing at UNC with @BenjaminGVincen to figure out which tumor-specific pMHCs are actually on tumor cells & which vaccine platforms are more immunogenic. Lots of long-read WGS/scRNA, targeted mass spec, tumor-specific TCRs coming your way in the near future

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Starting a new thing at UNC with @BenjaminGVincen to figure out which tumor-specific pMHCs are actually on tumor cells & which vaccine platforms are more immunogenic. Lots of long-read WGS/scRNA, targeted mass spec, tumor-specific TCRs coming your way in the near future

On behalf of the Intercept team, I’m excited to share that we’re launching our first “Request for Candidates”! We’re looking for the best science (and teams!) in the world that could plausibly meet our target product concept. Our ultimate goal is to radically reduce the burden of respiratory viruses, and an easy-to-use, safe, and effective preventative is a critical part of that puzzle. This request for candidates will be open until at least December 31st, but proposals received by October 12 will be prioritized. interceptfund.com/apply/broad-sp…

reminder to please reach out to me if you feel like something is Very Wrong in the world of life-science datasets. it seems like a pattern that some of the most useful datasets that exist came about from someone feeling like the current situation clearly made no sense

@owl_posting Agreed

AI will probably help translational medicine, but this field is much more climate-y than math-y imo. there are lots of science-shaped problems here, but far, far more human coordination problems that have misaligned incentives

There is a child with a rare disease who is currently suffering and struggling to manage his symptoms. Rare as this is, you can directly help him. Today we are launching the "Rare Disease, Real Kid" Hackathon, and there are $50,000 in prizes from @AnthropicAI and @awscloud. We (@huggingface & @Sagebio) are helping this child open his genome and clinical data to the community, so that we can find what's caused his disease and what currently-approved drugs could help him. I doubt I need to motivate this much further or explain how rare it is for a family to share their child's genome and clinical data, but if you're not sure, consider this: Until very recently, it wasn't feasible for patients like this to get treatment because their disease was so rare that the economics could never justify the investment. Now, as we've seen, people with rare diseases are starting to be able to find the answers themselves (with the help of AI tools, cheaper sequencing, etc). This kid is not able to do that for himself and neither are his parents, so we're asking you for help. Both for this kid and to prove that it's possible for everyone else suffering from a rare disease. More details in 🧵. …-real-kid-mva-hackathon-2026.hf.space

Incredibly saddened to hear about Maya’s passing. She was very generous with her time and deeply motivated to help change the outcomes for other rare cancer patients.

John Cumbers @johncumbers

a month ago

Remembering Maya Skubatch (1974-2026) Maya, a partner at @wilsonsonsini and one of the most respected patent minds in biotech, passed away last week after a five-year battle with a rare cancer called Blue Nevus Melanoma. She was 52. To the founders she represented, Maya was who

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In March 2024, at the age of 35, I was diagnosed with stage IV rectal cancer with a metastasis in my liver. This was a shock: I had no family history, and none of the doctors suspected it. After two years of chemotherapy, radiation, and multiple surgeries, I'm still not cured. Now I'm asking for help to get a personalized cancer vaccine. This is my story so far. Following diagnosis, I was treated with total neoadjuvant therapy at UCLA. I had 6 weeks of radiation and chemotherapy (Xeloda). This was followed by 6 rounds of oxaliplatin infusions and Xeloda. I tolerated this unusually well. During this period, I managed to hike up to over 11,000ft multiple times in the Sierras, and I wrote the main text of a 72 author meta-analysis paper and submitted it to Nature where it is still in review. I showed a good clinical response, and at the end of October I had surgery: I was under for 9 hours, and they cut out a bit of my rectum, 1/3rd of my liver, and gave me a temporary ileostomy. Waking up from this was probably the strangest experience of my life: I felt more machine than man, and I had wild hallucinations form such a large dose of anesthesia. It took a while to feel OK after that surgery. However, I still had the ostomy. I had that reversed at the end of January in another surgery, which took a greater toll on me than I expected. I only just started to feel OK again and I got bad news: I got a positive circulating tumor DNA test (ctDNA), the signatera test from natera. Unfortunately, the ctDNA carried on rising, and in July 2025 a new lesion appeared in a lymph node near my liver (periportal). I was treated with irinotecan and panitumumab infusions, which showed a good response, followed by live MRI guided SBRT radiation treatment to the lesion. However, after finishing this treatment, the ctDNA remained positive and began rising again. I restarted irinotecan and panitumumab infusions, which brought ctDNA back to negative (signatera), although it remained positive on the more sensitive Personalis assay. During this period I had begun to develop stomach pain and digestive symptoms. Then I collapsed vomiting blood while out in Santa Monica and was rushed to the ER. They found out I had a duodenal ulcer that had bled. I had some blood transfused, and I was sent home to complete an intensive course of antibiotics for H. Pylori infection. However, after about a week, I started to get very weak. I collapsed again and went back to the ER in an ambulance. They found my hemoglobin was 5g/dL, a dangerously low level (normal is over 13.5). Multiple blood transfusions didn't bring it up and I collapsed again in the night after passing a large amount of blood. They took me to intensive care and performed an emergency endoscopy where they clipped and sprayed the ulcer. Thankfully this worked and I was discharged after another 3 nights in hospital. Unsurprisingly, nearly bleeding to death wasn't good for me, and my ctDNA began to spike rapidly. I had a PET-CT and it revealed 3 new disease sites in abdominal lymph nodes. I restarted irinotecan and panitumumab infusions after barely recovering from the ulcer incident. This showed an excellent response, with the sites resolving on imaging, although ctDNA remained positive. I've now started bot/bal immunotherapy, a not yet approved immunotherapy treatment that is the first of its kind to show strong results in my kind of cancer, micro-satellite stable colorectal cancer. This was possible thanks to a donation from an anonymous benefactor and supporter of free and open inquiry in science. Hopefully this treatment will be effective, but it is unlikely to be enough on its own to prevent future disease recurrence. I am asking for help to get a personalized neoantigen cancer vaccine, which could substantially increase my chances of surviving this deadly disease that is likely incurable under standard care. While cancer vaccines have shown promising results, they are not yet approved, meaning one has to pay for the design, manufacture, and administration of the vaccine. The total cost of which is $104,133, beyond my means or those of my family. Any help would be greatly appreciated! I've started a GoFundMe here: gofundme.com/f/cancer-vacci…. Please donate and share with anyone who might be interested in helping. I've carried on working throughout this period and I'm still running a research group in statistical genetics at UCLA. I'm hoping to continue making contributions to science for as long as I can, hopefully longer with your help.

Also hate calling out @SouthwestAir on social media but > app not working > call wait time 2+ hours > no agents at gate, other gates have 20+ ppl in line

and no agents at gate and no rebook options! lol learned my lesson, paying extra to fly United (at least they have more flights for easy rebooking) not worth going with a more budget airline

not really a complainer & assume all airlines offer bad experience but @SouthwestAir really went above and beyond to suck lol > no comms as flight is getting delayed many times > says boarding & ppl line up, gate checking bags all morning > crew leaves ➡️ abrupt cancel via text