Turvey lab @TurveyLab
Dr. Stuart Turvey and the Turvey lab are commited to improving child health through research. Our research transforms lives. There is urgency to what we do! turveylab.com UBC and BCCH, Vancouver,Canada Joined February 2017-
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Access to #NewbornScreening for SCID is not yet universal around the world. This month, let’s continue to raise awareness, champion early diagnosis, and advocate for #SCID newborn screening for every baby, everywhere. #ScreenEveryBaby. Save lives. Change futures.
@anne_puel @casanova_lab @BeziatV (2/2) News & Views highlights two studies by Andersen et al. (rupress.org/jhi/article/2/…), and @turveylab (rupress.org/jhi/article/2/…)
Thank you to Anne, Jean-Laurent & Vivien for a thoughtful News & Views, and to Trine Mogensen & colleagues for the complementary study. Exciting to see OSMRβ deficiency emerge as a new inborn error of immunity through independent discoveries. @casanova_lab @anne_puel @BeziatV
.@anne_puel, @casanova_lab & @BeziatV discuss two studies reporting autosomal recessive OSMRβ deficiency as a new inborn error of immunity marked by severe atopy, hyper-IgE & eosinophilia, thereby refining the genetic dissection of STAT3 hyper-IgE syndrome hubs.la/Q04tysZr0
Thank you, Jean-Laurent! It means a great deal coming from you, Anne, and Vivien. We’re deeply grateful for such a thoughtful News & Views and for placing OSMRβ deficiency in its broader biological and clinical context. @casanova_lab @anne_puel @BeziatV
It was a pleasure to help @anne_puel and @BeziatV write this News & Views about spectacular discoveries by @TurveyLab and Trine Mogensen ! Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy rupress.org/jhi/article/2/…
Did you know there are more than 550 identified Primary Immunodeficiencies? 🤯 And researchers continue to discover more. Awareness leads to earlier diagnosis, and earlier diagnosis can save lives. 💙
Delighted to receive support from @CFI_FCI to advance our research into the genetic causes of severe allergic disease. Thank you to CFI for investing in the infrastructure that enables 🇨🇦Canadian researchers to turn discoveries into better health for patients.
🔬 Investing in the tools that drive Canada's future. Today, we announced more than $118 million to support 357 research infrastructure projects at 68 postsecondary institutions across the country. 🔗bit.ly/4bZ98jp
Our July issue is here! hubs.la/Q04ndpyG0 This cover highlights the first human biallelic OSMR deficiency. @TurveyLab et al. show that OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04ndtgx0
.@jhumimmunity July issue: hubs.la/Q04ndF0D0 This cover highlights the first human biallelic OSMR deficiency. @TurveyLab et al. show that OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE hubs.la/Q04ndBrH0
CHILD research out of @TurveyLab published in @NatureComms reveal that certain gut fungi 🍄 play a key role in the development of the immune system & in the development in kids of allergic asthma & some allergies. More: childcohort.ca/gut-fungi-key-…
Gut Fungi are Linked to Asthma Development | "Hundreds of millions of children worldwide are affected by allergic diseases, and the number is growing," said Dr. Stuart Turvey buff.ly/MH0aR72
Tiny gut fungi could be the key to treating Asthma worldwide thebrighterside.news/post/tiny-gut-…
Tiny gut fungi could be the key to treating Asthma worldwide thebrighterside.news/post/tiny-gut-…
👩⚕️Are you an MD? Maintain your medical certification by peer reviewing for CIHR! Learn more: cihr-irsc.gc.ca/e/53995.html?h…
Thanks for promoting our discovery @FranMartinezGr
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease #RareDisease #Genetics #morbidgene rupress.org/jhi/article/2/…
So great to partner with @SateeshMad93871 on this new discovery!
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
هكذا يتراكم العلم؛ ملاحظة تقود لاكتشاف، واكتشاف يفتح بابا لفهم أعمق. قبل سنة تقريبًا، وصفنا جين ال OSM كسبب جديد لفشل نخاع العظم، واليوم دراسة جديدة توضح أن نقص المستقبل المرتبط فيه OSMR deficiency يسبب أمراض حساسية شديدة ومبكرة. المثير للاهتمام أن الدراسة تلمّح لفكرة مهمة,غياب الجين نفسه يؤثر على تكوّن ووظيفة نخاع العظم، بينما غياب المستقبل يعطّل إشارات مناعية والتهابية مرتبطة بالجلد والحساسية. هذا مثال جميل على كيف أن نفس المسار الحيوي ممكن يرتبط بأمراض مختلفة تمامًا حسب موقع الخلل فيه.
تم التعرف على جين جديد يُسمى OSM مرتبط بحالات فشل نخاع العظم الوراثي، وذلك من خلال عمل بحثي شاركت فيه مع فريق علمي، ونُشر في مجلة The Journal of Clinical Investigation هذا العمل بدأ كحالة تحليل سلبي للاكزوم ، لكن من خلال إعادة قراءة التحليل الدقيقة، تمكنا من اكتشاف طفرة تؤدي
A new human inborn error of immunity: OSMR deficiency can underlie the HIES Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome rupress.org/jhi/article/2/…
A surprising and exciting observation ! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
👍👍I agree @Info4PI! For patients with inborn errors of immunity, genetic counseling helps families make sense of a genetic diagnosis while also advancing the knowledge that leads to better diagnoses, treatments, and outcomes for future patients.
🧬 Genetic counseling is a process that helps individuals and families understand the likelihood of a genetic condition and what that risk may mean for them. For families affected by #PrimaryImmunodeficiency, genetic counseling can provide clarity, guide decisions about genetic
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