Wiep Klaas Smits @SmitsLab
Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social lumc.nl/smits Leiden, Nederland Joined August 2015-
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Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut | Science Signaling science.org/doi/10.1126/sc…
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Wiep Klaas Smits retweeted
Inspired by Gibson cloning, we describe prime assembly, now published, for in cellulo targeted integration of gene-sized DNA fragments using prime editing. nature.com/articles/s4158…
Wiep Klaas Smits retweeted
Bacterial stress responses lower mRNA–protein level correlations | PNAS pnas.org/doi/abs/10.107…
Wiep Klaas Smits retweeted
Scientists have determined the highest-resolution protein structure obtained to date. Using advanced X-ray crystallography at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution. embl.org/news/science-t…
Wiep Klaas Smits retweeted
In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis. Congrats @christy_chc and the team! link.springer.com/article/10.103…
@PaulHoskisson I doubt that works on an outbound flight, though ;) first time this particular thing happens to me on KLM...
How is your day going so far? My trip to #ICDS2026 starts with an overbooked flight resulting in me arriving half a day later than expected (if all goes "well") after being rebooked... #mondayblues #flyingblue @KLM
@KLM but hey, at least I got a lunch voucher that will buy me exactly 1 sandwich...
This is a great study by @joeyzacks et al on "asymptomatic" carriage of Cdiff in infants. Must read! Early-life colonization with Clostridioides difficile remodels the developing gut | Science science.org/doi/10.1126/sc…
Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection | Infection and Immunity journals.asm.org/doi/10.1128/ia…
Multi-strain Clostridioides difficile infection: Increased detection and clinical implications. sciencedirect.com/science/articl…
Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/aa…
AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review sciencedirect.com/science/articl…
Very interesting! Novel surveillance design exploiting network analysis for efficient, rapid detection of emerging Clostridioides difficile strains nature.com/articles/s4146…
Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B–specific CD4+ T cell responses academic.oup.com/jimmunol/artic…
Wiep Klaas Smits retweeted
The narrowing prokaryote–eukaryote divide reveals a complexity spectrum dlvr.it/TV6wHZ
Wiep Klaas Smits retweeted
How to use AI in medical publications - the viewpoint from the JAMA editors 💡
Elucidating the pleiotropic effects of clpC deletion in Clostridioides difficile: proteomic and phenotypic insights sciencedirect.com/science/articl…
A TcdB-Targeting Antivirulence Compound Preserves Gut Homeostasis and Ameliorates Clostridioides difficile Infection pubs.acs.org/jafcau/article…
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