NIASCEND | Dr. Dmitry Kats @NIASCEND
Epid @UNCpublichealth | Biostats @usfcoph | Math/CS @XavierU | Biochem @TulaneCBE || 🚀 Ascending beyond just healthy aging mandates https://t.co/JE2bhVjCml 💎 pubmed.ncbi.nlm.nih.gov/?term=Kats+Dmi… ∞ Joined October 2023-
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@AllArsenalStuff @DovySimuMMA From the UFC roster like MVP did who beat him who had only was it 1 UFC loss?
@AllArsenalStuff @DovySimuMMA Question is Shara will get dropped too?
@SmartScience @GPR109A Some context:
@MarcioBarra1 @matthewherper Bayesian MCMC joint models unbiasing observational prospective data to simulate as if double-blind RCTs over the lifecourse—methods I utilized for my (epidemiology) dissertation—uncovered the "cause of disease" and confirmation of the same causal fix already demonstrated pre-WW2.
@SmartScience @GPR109A While immortality for lab rodents was shown ~30 yrs ago to be fulfilled by solely L-tryp, modern-day, higher-ordered living organisms endure much greater NAD+-demand—i.e. need for dynamic counter of oxidation to sustain energy metabolism (function/life) that would exhaust L-tryp.
It’s true.
@MarcioBarra1 @matthewherper @UNC Imagine this not being true.
@MarcioBarra1 @matthewherper @UNC Imagine this not being true.
@SmartScience @GPR109A While immortality for lab rodents was shown ~30 yrs ago to be fulfilled by solely L-tryp, modern-day, higher-ordered living organisms endure much greater NAD+-demand—i.e. need for dynamic counter of oxidation to sustain energy metabolism (function/life) that would exhaust L-tryp.
@MarcioBarra1 @matthewherper @UNC Hopefully not but as all this truth stays not being taken seriously just b/c such complexity comes down to somethings so simple (or are they!?), as hand-waved allegorical vibes free of results even actual substance reign supreme, the best I can do is hope each next-gen rendition:
Just take the methionine part out.
Nicotinic acid increases adipose tissue dietary fatty acid trapping and reduces postprandial hepatic and cardiac fatty acid uptake in prediabetes sciencedirect.com/science/articl…
💨
@SmartScience @GPR109A W/o NIASCEND, already-exhausted L- (as a result of: whether from not a drop of any kind of niacin ‘equivalency’, in a matter of weeks; or if NAD+ was there to livable degree but remained inadequate over the life course) will grow even more unavailable to fulfill its duties til 💀
@EliLillyandCo @novonordisk R.I.P.
@SmartScience @GPR109A W/o NIASCEND, already-exhausted L- (as a result of: whether from not a drop of any kind of niacin ‘equivalency’, in a matter of weeks; or if NAD+ was there to livable degree but remained inadequate over the life course) will grow even more unavailable to fulfill its duties til 💀
@EliLillyandCo @novonordisk The life course—and all the ways the living organism system breaks down on the way—are this same exact, underlying mechanical pellagric breakdown process, just manifesting over a prolonged scale—which 15 mg niacinamide + “B vitamins” to make tryp degradation less taxing afforded.
@SmartScience 6/9 COVID also perturbs tryptophan metabolism: lower tryptophan & higher kynurenine/tryptophan ratios are repeatedly reported, pointing to inflammatory IDO-driven activation & altered metabolic demand—complications niacin + DL-tryptophan would have averted but will still reverse.
“Thus, tryptophan-selective lipidated GLP-1 peptides are as effective as conventional GLP-1 RAs in reducing plasma glucose levels and body weight and may represent a less demanding method of manufacture of GLP-1 RAs.” journals.bioscientifica.com/joe/article-ab…
^ Just like "advanced peptide signaling" did for DL-tryptophan! x.com/NIASCEND/statu…
@EliLillyandCo @novonordisk Only the "peptide/GLP1RA" side is same as if these pups (sciencedirect.com/science/articl…) upon receiving ‘folic acid’ extract = D/L-tryp to release its essential limitation were further accelerated along pellagra by never relieving NAD+ demand w/ adequate niacin: sciencedirect.com/science/articl…
@EliLillyandCo Are you going to continue to also conceal how your “GLP-1RAs” are just sophisticated pharmacological coverup of downstream indole metabolites of DL-tryptophan?
"Thus, tryptophan-selective lipidated GLP-1 peptides are as effective as conventional GLP-1 RAs in reducing plasma glucose levels and body weight and may represent a less demanding method of manufacture of GLP-1 RAs."
An oldie but a goodie (need the full? Comment below) Niacin Reduces Paraquat Toxicity in Rats science.org/doi/10.1126/sc…
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