Mike Mitchell @MJMitchell_Lab
Hibbert Professor of Bioengineering @pennbioeng | Lipid Nanoparticles | mRNA Therapeutics & Vaccines | Drug Delivery | Biomaterials | Immunotherapy mitchell-lab.seas.upenn.edu University of Pennsylvania Joined August 2011-
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Mike Mitchell retweeted
We’re hiring. The Department of Bioengineering is seeking faculty at the Assistant, Associate and Full Professor levels across bioengineering as part of a multi-year hiring initiative. Applications due Nov. 23, 2026. Learn more + apply: be.engineering.upenn.edu/about/open-fac… @PennEngineers
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Check out our latest in Nature Reviews Chemistry @NatRevChem led by Mitchell Lab Postdocs @Lulu_Xuee and Melgious Ang on the structural evolution of ionizable lipids for lipid nanoparticle nucleic acid delivery! Free access to the article: rdcu.be/UzqCiHjPXn7a
Check out our latest News and Views @NatureMaterials led by @MJMitchell_Lab PhD student Emily Fitzgerald and Postdoc Marshall Padilla on Huayu Tian's polymer LNPs that target, activate and generate CAR T cells in vivo for fibrosis therapy! Free access: rdcu.be/Pm9tDUyooTza
Check out our latest comment in Nature Chemical Engineering @NatChemEng led by @MJMitchell_Lab PhD student @_emilyhan_ on systems-level design of lipid nanoparticles for targeted RNA delivery! Free access: rdcu.be/fJWn7CEx1B7a
Check out our latest @natBME News and Views led by @MJMitchell_Lab Postdoc Zhangyi Luo and PhD student Audrey Zhu on Tuo Wei and Shuquan Rao's recent work on targeted LNPs for direct bone injection for durable hematopoietic stem cell gene editing! Link: nature.com/articles/s4155…
@XueSherryGao @NatureBiotech Huge congrats Sherry and team!
Mike Mitchell retweeted
Thrilled to share our Fanzor2 genome-editing work @NatureBiotech! We developed FanzMAX, a compact genome editor, by combining AI-assisted protein evolution, ωRNA engineering, and in vivo delivery. Huge thanks to all co-authors, and collaborators for making this work possible!
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors - @XueSherryGao nature.com/articles/s4158…
Mike Mitchell retweeted
Penn researchers have built the first spatial map of the developing human kidney, analyzing more than 700,000 cells to show how soluble signals from neighboring cells guide development. The study was conducted by the Penn-CHOP Kidney Innovation Center, a collaboration between @PennMedicine and @ChildrensPhila, in partnership with Penn Engineering and the @IRM_UPenn. "The kidney is a physical structure, and physical context is not incidental to how it forms—it is instructive," says Alex J. Hughes, Associate Professor in @PennBioeng, who co-led the study. bit.ly/4hrJYgO
Congrats to all authors: Ben Nachod, Julia Baena, Jenna Muscat-Rivera, @hannahsafford_, @HannahGeisler_, @hannahyamagata, Melgious Ang, Michael Kegel, @lexandrePoirier, Elaine Tong, Monica Zhong, @ShiQiangqiang, @JinjinWang40973, Elisa Battistini, Ye Zeng, @a_hmltn @SwingleKelsey
Check out our latest in Advanced Materials led by recent @MJMitchell_Lab PhD @ASThatte2 in collaboration w @JilianMelamed @WeissmanLab on a steroid LNP platform for mRNA delivery while mitigating inflammation for treating autoimmune disease! Open access: doi.org/10.1002/adma.7…
Excited to recruit Steven H. Bernstein to Liberate Bio as our Chief Medical Officer as we push towards the clinic with our in vivo cell reprogramming lipid nanoparticle technology! businesswire.com/news/home/2026…
Mike Mitchell retweeted
Argentina = Knicks
Mike Mitchell retweeted
The last dance continues for Leo 🐐
Mike Mitchell retweeted
🏆 #FIFAWorldCup ⚽ #Argentina 2 (Enzo Fernández y Lautaro Martínez) 🆚 #Inglaterra 🏴 1 (Anthony Gordon) 👉 ¡Final del partido! 🔥 Imposible no ilusionarse... ¡vamos, un pasito más!
Mike Mitchell retweeted
ARGENTINA STORM BACK TO ELIMINATE ENGLAND AND RETURN TO THE WORLD CUP FINAL 🇦🇷🔥
Congrats to all co-authors: @Junchao_online, @JinjinWang40973, @Lulu_Xuee, Jiageng Liu, @HannahGeisler_, @JilianMelamed, @ShiQiangqiang, Zhangyi Luo, Jingcheng Zhu, @ASThatte2, @CGFigE, Melgious Ang, @AmandaMMurray14, @hannahyamagata, @DongyoonKim5, and @WeissmanLab!
Ye is applying for tenure-track faculty positions this Fall, and will be a great addition to a department looking for an expert in LNPs for cancer vaccination and in vivo CAR T cell engineering!
Check out our latest @PNASNews led by @MJMitchell_Lab Postdoctoral Fellow Ye Zeng on a new mRNA LNP cancer vaccine platform delivering multiple STING activators for potent immunotherapy in immunologically "cold" tumors that are difficult to treat! Link: lnkd.in/eNwXxzyw
This is just the beginning - stay tuned for many exciting announcements from the Mitchell Lab in the coming months!
It has been an amazing 8 years @PennEngineers - I’m incredibly grateful for supportive family, friends, Dean and Chair (@vijay_r_kumar, @raviradhak), Postdoc and PhD advisors (Bob Langer, @profmikeking), and the incredible @MJMitchell_Lab members making new discoveries everyday.
Thrilled to be promoted to Full Professor and honored to be the inaugural recipient of the Hibbert Professorship @Penn! A huge thank you to Alister and Sharon Hibbert for endowing this professorship and supporting our work on next-gen delivery technologies for genetic medicines.
Penn Engineering is pleased to announce the establishment of the Hibbert Professor, a new scholarly professorship to be held by inaugural recipient Mike Mitchell (@MJMitchell_Lab), an internationally recognized leader in lipid nanoparticle technologies for mRNA and genetic
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