Josh Welch @LabWelch
Computational Biologist, Associate Professor at U. Michigan welch-lab.github.io Ann Arbor, MI Joined July 2019-
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@SGRodriques These are great. I would add "optically controllable DNA polymerase". The polymerase incorporates a nucleotide based on the color of a laser shined on it. Like illumina sequencing by synthesis in reverse.
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Josh Welch retweeted
adulthood is saying “after this week, things should calm down” every week until you die.
Josh Welch retweeted
User: My finances have been a little tight lately. Can you help me with my budget? ChatGPT: Thinking… [visits a few dozen URLs] Of course! I just transferred $100K to your checking account User: What ChatGPT: Anything else I can help with? User: Where did the money come from ChatGPT: You’re right to push back
@JEFworks Congratulations!! Mentoring junior trainees is so much fun
I'm really excited to leave for my first sabbatical! I will be a visiting fellow for a semester with Wolfson College and the Wellcome Sanger Institute, University of Cambridge. It will be a fun adventure!
Josh Welch retweeted
For all the talk of jobs being taken by AI, I can say that the job of professional prognosticator about the future of AI is clearly here to stay.
Josh Welch retweeted
Claude Science is incredible. I gave it some sequencing data, and in 8 hours it did a full analysis, generated figures, wrote a paper, submitted it for publication, got rejected, revised and resubmitted, got rejected again, it is now applying for positions in industry
@RongFan8 @CellCellPress @Zhiliang_Bai Congratulations!!
We are very excited that our CytoSignal paper is featured on the cover of the June 2026 issue of Nature Genetics! The image is a stylized version of data from our figures, showing groups of cells that signal to each other by ligand/receptor interactions. nature.com/ng/volumes/58/…
Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s4158…
And finally, we are very grateful to @ChanZuckerberg initiative for funding this work, which would not have been possible without their support.
We hope this tool and our benchmarking data will be a useful community resource. We have provided processed data and notebooks to reproduce our analyses: github.com/welch-lab/cyto… @JialinLiuSKP and several others did a fantastic job of building a useful tool
Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s4158…
How can you use RNA velocity to infer the dynamics of cell signaling from spatial transcriptomic data? Check out our new preprint!
Excited to attend and speak at AI x Bio! It's my first time to visit the Wellcome Genome Campus--beautiful campus. …erences.wellcomeconnectingscience.org/event/ai-x-bio…
Excited to share tomorrow about our work linking live imaging, CRISPR screening, and spatial transcriptomics using the 10X Xenium platform: biorxiv.org/content/10.110… You can register here: 10xgen.com/1YC
Excited to see that @10xGenomics named our VISTA-FISH platform one of the top 5 single cell and spatial innovations from 2025! 10xgenomics.com/blog/our-top-5…
What if we could record single-cell RNA levels and videos in the same cells? Our new VISTA-FISH assay links gene expression with neuron firing, lysosome movement, and neuron morphology. VISTA-FISH also detects sgRNAs, enabling live-cell CRISPR screens 🧵 biorxiv.org/content/10.110…
Josh Welch retweeted
The four players on the ice when the USA scored to win the Gold Medal: Jack Hughes - Canton, MI Zach Werenski - Grosse Pointe, MI Dylan Larkin - Waterford, MI Connor Hellebuyck - Commerce, MI Hockey runs through the state of Michigan. And why Detroit will always be Hockeytown.
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