Magali IRLA Lab @IrlaLab
Our lab studies the mechanisms of thymic T-cell tolerance. We develop innovative strategies to regenerate the thymic function and treat autoimmune diseases. ciml.univ-mrs.fr/fr CIML Marseille France Joined February 2022-
Tweets80
-
Followers143
-
Following125
-
Likes200
Thrilled to share that our review in @ScienceAdvances is out!🧬We highlight how age-related thymic involution alters T-cell immunity and discuss therapeutic strategies to rejuvenate thymic function and promote healthier aging. #immunology #Aging #thymus science.org/doi/10.1126/sc…
Having a great time with the team ! #immunology #CIML
@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/sc…
New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe
We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system.
This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.
Thrilled to share our latest research in @ScienceTM ! We show that RANKL administration reverses age-dependent thymic involution and rejuvenates T cell immunity. @CIML_Immunology #aging #thymus #Tcells #Immunology #Involution #Rejuvenation science.org/doi/10.1126/sc…
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/sc… @ScienceTM
I remember being blown away when @IrlaLab showed me these data @CIML_Immunology 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice @ScienceTM science.org/doi/10.1126/sc…
A new study on @ScienceTM finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging @JrmyCSantamaria, Dr.Magali Irla @IrlaLab, Antoine Toubert of @univ_paris_cite, et al. science.org/doi/10.1126/sc…
@OstuniLab @CIML_Immunology @ScienceTM Thank you Renato 😉
Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML
Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders, but when it ages prematurely due to a lack of vitamin D, it becomes less effective. This increases the risk of autoimmune diseases like type 1 diabetes, as the immune system may mistakenly attack healthy tissues. The research underscores the importance of adequate vitamin D intake, particularly during "vitamin D winter" when sunlight is insufficient for natural production. Ensuring children receive proper vitamin D supplementation during these months could help prevent autoimmune disorders.
Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell cell.com/developmental-…
Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0
New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue…
Darren Moore @you_little_twit
3 Followers 5 Following
Amanpreet Singh Chawl... @APC82236815
691 Followers 5K Following Immunologist, Biologist, opinions are my own.
Letícia Figueiredo @figueiredolsf
176 Followers 1K Following PhD Candidate at @MoriLabe | Immunometabolism & aging | Adipose tissue, thymic involution, immunosenescence & extracellular vesicles.
Divya S @Divya__S
17 Followers 211 Following She/Her | Research Assistant @jncasr | MSc Biotechnology and Bioinformatics graduate @official_ibab | #immunology #bioinformatics
Yunhao Zhai @YunhaoZhai
168 Followers 161 Following Technology development fellow @wyssinstitute @Harvard, Ph.D at Malissen lab @CIML_Immunology. Immunology, Lymph node organ chip, immunotherapy.
Yousef Ijjeh @YIjjeh
1 Followers 259 Following
Zou🦭 @alcf_zou
29 Followers 86 Following
Mathias Mahnke @MathiasMahnke
15 Followers 145 Following
Fajar Pm @fajar__pm
51 Followers 287 Following PhD student @ULBruxelles Alumni @IISERpune. In awe of the immune system's hidden symphony
Matthew Gubin @GubinMatthew
1K Followers 3K Following Tumor Immunologist at The University of Texas MD Anderson Cancer Center and Parker Bridge Scholar @Parkerici @MDAndersonNews Views are my own.
Miguel Marin-Rodero, ... @Miguel_Marin_R
210 Followers 420 Following Postdoc at CBDM lab @HarvardMed 🇪🇸🇺🇸 Passionate about immune tolerance, neuro-immune interactions, and immune tissue crosstalk!
Preetam Basak @PreetamBasak1
19 Followers 370 Following Postdoctoral Research Scientist. Columbia University Irving Medical Center. Type 1 Diabetes immunology
Sriram Kumar, Ph.D @sriramkumarskr
848 Followers 4K Following IFNs/STATs/ISGs, Innate Immunity, RNA Viruses. Young @GesVirologie Board 2021-23, @iuis_junior @y_efis and @YI_dgfi Board 2023-27, @iGEM Biosecurity. #DEI 💪🏼
Renato Ostuni @OstuniLab
2K Followers 319 Following Ultra-Professor at San Raffaele Institute, Milan. Immunity, Cancer, Genomics, Gene Therapy, and Ultra-Running. Here and "there" at https://t.co/vllLM9lUHt
jackie howells @jackiehowells1
2K Followers 7K Following Curious human~PhD candidate at Brown. ecologist at heart~ immunology~ systems biology (ecology)~ mentorship & inclusive access~aesthetics | views are my own
Sean S. @SeanS158374
0 Followers 24 Following
Dr Lena Alexopoulou @AlexopoulouDr
1 Followers 4 Following
Siddharth @sid_ereal
112 Followers 590 Following PhD scholar in Immunology with @ugur_milas at @Kamu_lab @Wue_SI |@IISERPune BS-MS Graduate|
PicoLab @LabPico
441 Followers 473 Following Small young (pico) immunology lab in @SapienzaRoma. PI is Silvia Piconese. In love with regulatory T cells. (Thanks to @daisychungart for the profile pic)
Molly Dunlop @MollyDunlop10
66 Followers 162 Following PhD student @MaynoothUni / @KEnglishlab Investigating trained immunity in allergic asthma 🫁
Syed Bilal Andrabi @bilal_ibu
309 Followers 3K Following Senior Researcher @University of Turku@ InFLAMES flagship,Turku, Finland.
Jayendra Singh @Jayen_singh
166 Followers 677 Following PhD student @PetermacCC, Melbourne• MS from @hiv_lab, JNCASR• BSc Zoology from Institute of Science, @bhupro• Interested in studying the Immune System.
RattayLab @RattayLab
55 Followers 124 Following Immune Tolerance and Autoimmunity Research Laboratory @Uni_MR
Rahman LAB @rahmanLAB2023
196 Followers 1K Following HIV-focused research lab of @sheikhrahmanPhD @EmoryUniversity. Opinions are Dr. Rahman's alone and do not represent Emory University.
Actually Published @ActuallyPblishd
1K Followers 3K Following Real quotes from peer-reviewed scientific articles.
ImmuNoah'sArk @immunonoah
1K Followers 2K Following Passionate about biomedical science & immunology, the universe and every now and then some good old fashion fantasy 🏳️🌈 (he/him). Opinions are my own.
Waggoner Lab @LabWaggoner
13K Followers 8K Following Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer. @labwaggoner.bsky.social
Bertoia Lucas @lucasbertoia_
2 Followers 41 Following
Masahiro Ono @ Tocky ... @MonoTockyLab
782 Followers 610 Following Experimental × computational immunology｜MD PhD FHEA｜T cells, immunotherapy & cancer｜Tocky & GatingTree developer｜🇯🇵@masahirono
Sophie Guia @sguiads
5 Followers 13 Following
CIML @CIML_Immunology
2K Followers 210 Following The Centre d’Immunologie de Marseille-Luminy is all about Immunology in every aspect. CNRS UMR7280, Inserm U1104, AMU UNIV UM2
Enrico Velardi @Velardi_Lab
135 Followers 158 Following Our laboratory at the @BambinoGesu Children Hospital in Rome studies mechanisms regulating #immunereconstitution after damage - @AIRC_it @BeTheMatch @ASTCT
Cécile APERT @CecileApert
21 Followers 64 Following postdoctoral fellow at @miupasteur - Microenvironnement & immunity
Julia Gensheimer, PhD @juliagensheimer
341 Followers 583 Following MD candidate @dgsomucla @uclacaltechmstp | PhD in Molecular Biology | founder @medmentorsorg @medmentorsucla
lucas bremond @lucas_bremond
23 Followers 182 Following PhD Student in Pierre Milpied’s Lab (@CIML_Immunology)
Sandrine Henri @henri_sandrine
800 Followers 321 Following Immunologist at Center for Respiratory Diseases, Inserm U1100, Tours University, #Myeloid Cells #Lung #Pathogens; Love Running & Swimming; Proud Mother 💖💝
Monsonego Lab @MonsonegoLab
165 Followers 291 Following Immune regulation, autoimmunity, aging, neurodegenerative diseases, chronic stress, glial biology, T cell therapy
Fernanda Escobar-Riqu... @Feernicole2
377 Followers 2K Following Chilean, Biochemist, PhD in Immunology and Immunotherapy, Postdoctoral Research Fellow at UCL, London. Member of the @BSI_TumourImm ✈️📚🍫🏞️👩🔬🎨❄️
Md Sahidul Islam @Islam_Sahidul06
29 Followers 373 Following Pre-Doctoral Candidate @RoswellPark || Alumnus @UM_1981 || Alumnus @NSTU_Bangladesh
Zhangfan Ding, @DingZhangf75677
1K Followers 4K Following Clinician Scientist: Kusumbe Lab & in Sichuan University
Inserm @Inserm
148K Followers 356 Following Institut national de la santé et de la recherche médicale. La science pour la santé.
Nature Medicine @NatureMedicine
358K Followers 257 Following Nature Medicine is a research journal devoted to publishing the latest advances in translational and clinical research for scientists and physicians.
Matthew Gubin @GubinMatthew
1K Followers 3K Following Tumor Immunologist at The University of Texas MD Anderson Cancer Center and Parker Bridge Scholar @Parkerici @MDAndersonNews Views are my own.
Renato Ostuni @OstuniLab
2K Followers 319 Following Ultra-Professor at San Raffaele Institute, Milan. Immunity, Cancer, Genomics, Gene Therapy, and Ultra-Running. Here and "there" at https://t.co/vllLM9lUHt
Dr Lena Alexopoulou @AlexopoulouDr
1 Followers 4 Following
Iannacone Lab @iannaconelab
3K Followers 640 Following 🔬Dynamics of immune responses to pathogens and tumors. 📍San Raffaele Scientific Institute & University, Milan @SanRaffaeleMI @MyUniSR
ThymUS2025 @ThymUS2025
6 Followers 10 Following Join us in Kauai, Hawaii for the ThymUS 2025 conference from April 27 - May 1!
PicoLab @LabPico
441 Followers 473 Following Small young (pico) immunology lab in @SapienzaRoma. PI is Silvia Piconese. In love with regulatory T cells. (Thanks to @daisychungart for the profile pic)
RattayLab @RattayLab
55 Followers 124 Following Immune Tolerance and Autoimmunity Research Laboratory @Uni_MR
Waggoner Lab @LabWaggoner
13K Followers 8K Following Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer. @labwaggoner.bsky.social
Elisa Eme-Scolan @eemescolan
77 Followers 179 Following Postdoc at Massachusetts General Hospital & Harvard Medical School 🇺🇸 PhD at the CIML 🇫🇷 #Neuroimmunology and #Osteoimmunology enthusiast 🔬🧠🦴
Courtney Malo @courtney_malo
535 Followers 657 Following Senior Editor for #immunology, #infection, #immunotherapy, and #vaccines at @ScienceTM. @MayoGradSchool and @UofSC alum. She/Her. Opinions are my own.
Institut Marseille Ma... @marmara_amu
180 Followers 130 Following True to its values of respect, tolerance and humanism, the MarMaRa institute (AMU) has decided to suspend its activity on X.
Sophie Guia @sguiads
5 Followers 13 Following
Vera Martins @Vera22380790
294 Followers 136 Following We study T cell development in physiological conditions and in leukemia.
Cécile APERT @CecileApert
21 Followers 64 Following postdoctoral fellow at @miupasteur - Microenvironnement & immunity
Martin Guilliams @MartinGuilliams
6K Followers 919 Following Immunologist with chronic passion for macrophages, fascinated by Kupffer cells, Proud dad of two princesses.
THE DUMENIL LAB @DumenilLab
633 Followers 307 Following Whatever it takes to discover exciting new mechanisms of host pathogen interactions
Monsonego Lab @MonsonegoLab
165 Followers 291 Following Immune regulation, autoimmunity, aging, neurodegenerative diseases, chronic stress, glial biology, T cell therapy
ImmunoPasteur @ImmunoPasteur
1K Followers 197 Following The Department of Immunology at Institut Pasteur, Paris, France
Taras Kreslavsky @TKreslavsky
484 Followers 313 Following
Zhangfan Ding, @DingZhangf75677
1K Followers 4K Following Clinician Scientist: Kusumbe Lab & in Sichuan University
eLife - the journal @eLife
176K Followers 694 Following The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity
Maria Jenmalm🏳️�... @mjnmlm
917 Followers 3K Following Professor of Experimental Allergology, Linköping University, Sweden. Interested in diversity & how early microbial exposures shape infant immune development🤰👶
CFCD @_cfcd
611 Followers 616 Following Club Francophone des Cellules Dendritiques - French Dendritic Cell society. We organise international meetings on dendritic cells.
SoHillion @SoHillion
189 Followers 739 Following PhD Immunology @InsermU1227 #Bcell#Autoimmunity @UBO_UnivBrest @CHRU_Brest
Bio-protocol @bioprotocolbyte
3K Followers 269 Following Bio-protocol publishes #openaccess, peer-reviewed life science protocols. 🌟Now Connect with us on Bluesky: https://t.co/IeYMp18OHm
Marion Lenain @LenainMarion
57 Followers 179 Following PhD - Use of γδ T cells armed with monoclonal antibodies as a new cancer cell therapy - Immunity & Cancer Team - @IRCM_MTP #immunity #gammadelta #tcell
Martine Cohen-Solal @martine_solal
100 Followers 98 Following
The Kusumbe Lab @Anjali_Kusumbe
1K Followers 5K Following Vascular & Tissue Biology lab led by Anjali Kusumbe @KusumbeLab (stem, immune & cancer cells) Account managed by lab members
Lena Boehme @lenamboehme
87 Followers 161 Following Postdoctoral Researcher & γδ T cell fan | studying T cell development in the human thymus @taghon_lab @UGent | she/her 👩🔬💻 | https://t.co/XttsqxZsid
AKAME @Akame_VAL
264 Followers 1K Following 26 y.o - VALORANT player for ??? | ex-CS GO player 🇫🇷 Faceit 10 | PhD Immunology Student 🔬
Immune Regulation New... @Immune_News
10K Followers 837 Following An online resource for researchers studying the activation, suppression, and modulation of the immune system. Part of the @STEMCELLTech Science News service.
Guillaume Hoeffel @HoeffelG
209 Followers 346 Following
Pieter Goossens lab @PiGoossensLab
385 Followers 308 Following Pieter Goossens lab at the Maastricht University, #macrophage #inflammation #atherosclerosis
Antonino Cassotta @cassottalab
461 Followers 917 Following My lab dissects the human T cell repertoire targeting tumor and self-antigens. Learning from nature, we aim to engineer improved immunotherapies.
GDR ImaBio @GDR_ImaBio
1K Followers 469 Following 🔬 Animating the #french #community of #scientists and #companies involved in #microscopy and #imaging for #biology 👉 https://t.co/cztsXhgz4S
ICIS 🦋 @cytokineso... @CytokineSociety
4K Followers 1K Following The ICIS is devoted to research in the fields of cytokine, interferon and chemokine cell biology. Cytokines 2025, 2-5 November in Seattle. Follow us on BlueSky.
Guignard Lab @GuignardLab
825 Followers 350 Following Computer Science, Morphogenesis & Variability: From developing code to decoding development. @IBDMmarseille Open positions: https://t.co/m9vyXuEzSU
Nuit Européenne des ... @NuitChercheurs
4K Followers 912 Following Édition française de La Nuit Européenne des Chercheur·e·s soutenue par la Commission Européenne. RDV le vendredi 29 septembre 2023 #NuitChercheurs
Stefi Vargas @StefiVargasA
305 Followers 737 Following Heart Regeneration & Immunology 🫀 Postdoc at @lab_olson. From 🇪🇨
GGuaschResearch @GGuaschResearch
416 Followers 426 Following Tenure Research Director Inserm, Ph.D, HDR - Epithelial Stem Cell & Cancer Research / Cancer Research Center Marseille ORCID iD : https://t.co/LDoIXtHV5t
Geoffrey Guittard @GeoffGuittard
73 Followers 110 Following Researcher at CNRS in immunotherapy at the cancer research Center or Marseille, France
Saidi SOUDJA @SaidiSoudja
90 Followers 283 Following
Anais Roger @AnaisRger
107 Followers 152 Following Ph.D in Neuroimmunology 🇫🇷 | Post-Doctoral fellow 🇨🇦
Nelson Dusetti 🇫�... @NelsonDusetti
2K Followers 5K Following Translational research in pancreatic cancer - @crcm_marseille - INSERM U1068You might like
