Ignatova Lab @IgnatovaLab
A lab of #RNA lovers, obsessed with tRNA, translational control in protein biogenesis and disease. #translation #ribosome #mRNA #tRNA #SNP 🇺🇦 chemie.uni-hamburg.de/bc/ignatova/ Hamburg, Deutschland Joined June 2018-
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@rubenlgonzalez @Nature Congrats Ruben! Terrific stuff!
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Ignatova Lab retweeted
The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation: trna2024kanazawa.jp #tRNA2024
Ignatova Lab retweeted
That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.
Now online! Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient dlvr.it/TDnc6w
Highly recommended! PhD students apply
We are looking for a highly motivated PhD student to explore molecular mechanisms of protein synthesis using fast kinetics and cryo-EM. Pls share the link or apply! uu.varbi.com/en/what:job/jo…
Ignatova Lab retweeted
At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24
Ignatova Lab retweeted
Preprint alert in collaboration with @fraser_lab ! We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation! Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.110…
Ignatova Lab retweeted
We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders
Ignatova Lab retweeted
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…
Ignatova Lab retweeted
Single-cell proteomics helped answer a fundamental question in development: The molecule mechanisms of symmetry breaking in early mammalian development. A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.
We are looking for a highly motivated PhD student to explore molecular mechanisms of protein synthesis using fast kinetics and cryo-EM. Pls share the link or apply! uu.varbi.com/en/what:job/jo…
@DjuranovicLab What fo they tell us, besides being more :)
Ignatova Lab retweeted
How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in @PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk
@JanUlrikDahl1 @IllinoisStateU @ISUResearch Awesome Jan! It not only rains on your street, it poors - hsppy for you! Looking forward to seeing you soon in HH and catching up :)
Ignatova Lab retweeted
I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s4158…
@MiriKrupkin @D_Rothschild_ @mbarnalab @jkpritch @xsui98 @WangXiaoLab @spence_jeffrey_ Congrats Daphna!
Ignatova Lab retweeted
Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM
@chofski @BristolUni @BristolBioSci @BrisBioDesign @JGIBristol @turinginst @royalsociety Congratulation, Tom! Fully deserved!
Happy (t)RNA day! #RNADay Thank you to our first author baker Vale @Vblancoca - our terrific guest from @jptosar lab - who orchestrated the baking process.
Happy #RNADay! 🎉 Celebrating in Germany with the incredible scientists/bakers at @IgnatovaLab Check out our entry for the @RNASociety cake competition! 🍰🔬 We hope sharing our creation here is as welcomed as uploading a paper on @biorxivpreprint🤞 @jrRNAscientists
@OdedRechavi Cool stuff! Can you deliver other macromolecules? Small RNAs?
Ignatova Lab retweeted
The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…
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