Elting Lab @EltingLab
Mechanics of cell division across length scales. We shoot cells with lasers. | Physics Department @ NCSU. go.ncsu.edu/eltinglab Raleigh, NC Joined July 2016-
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Please note that we’re hiring at all levels for experiments related to this project!
Mary Elting @mwelting @EltingLab laser ablated spindles and nuclear envelopes in the yeast S. pombe, which has closed mitosis, and showed that the spindle can shape the nuclear envelope. The spindle and the nuclear envelope are a mechanical pair whose properties are well matched.
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Such clear and compelling translation of theory to its biological significance, helping us understand what regimes and parameters may be important for the spindle.
Sebastian Furthauer @SFuerthauer developed a theory that predicts how the micro-scale properties of motor proteins and crosslinks tune the network emergent properties and generate behaviors such as microtubule poleward flux in Xenopus egg extracts. #SpindleCroatia2023
This talk beautifully demonstrated another mechanism spindles can use to redundantly adapt to stress and ensure bipolarity. Will be interesting to see if this is Kif15 dependent!
Brittany Salazar @B_B_Beast from @R_Ohi_Lab asked how cells build a spindle without EG5. She showed that PRC1-mediated bundling of spindle microtubules creates a favorable environment for KIF15-driven spindle assembly under EG5 inhibition. #SpindleCroatia2023
Exciting talk from Katya Grishchuk demonstrating a novel slow binding site ‘maturation’ that may help ensure the kinetochore forms in the right place rather than free in solution. Super beautiful work! #SpindleCroatia2023
Elting Lab retweeted
Mary Elting @mwelting @EltingLab laser ablated spindles and nuclear envelopes in the yeast S. pombe, which has closed mitosis, and showed that the spindle can shape the nuclear envelope. The spindle and the nuclear envelope are a mechanical pair whose properties are well matched.
@Dey_Gautam 🤦🏻♀️ I definitely should have. Next time!
#SpindleCroatia2023 continues to impress with amazing AFM movies from Radhika Subramanian resolving depolymerization of individual microtubule protofilaments!
Great kickoff to #SpindleCroatia2023 by @SueBiggins ! Beautiful work watching the dynamics of kinetochore assembly in vitro.
Elting Lab retweeted
An elegant and compelling dispatch by Mary Elting @EltingLab highlighting the role of the augmin complex for the construction of mitotic spindle bridging fibers, which support accurate chromosome segregation. Thank you! @CurrentBiology @CellPressNews cell.com/current-biolog…
@Toliclab @CurrentBiology @CellPressNews @MarcusABegley and I had fun writing it! It’s a great paper. Glad to hear you like it!
Check out more details about Marc’s project at board B173 today. Also, he’s graduating and on the hunt for a postdoc in the NJ/NYC/PHL area, so if you’re hiring, come chat with him!
Excited for the “Nuclear Power” session starting now! Marc Begley from our lab will be giving the last talk of the session examine how the spindle and nuclear envelope mechanically shape each other in fission yeast closed mitosis. #cellbio2022
Also - I’m having my normal response to these amazing movies of icthyosporea’s suddenly explosive division: can I shoot a laser at that? Please @Dey_Gautam ?
#ASCB2022 always makes me wish I could be in two places at once. Luckily session layout makes it possible to hop over to the Evolutionary Cell Bio subgroup to hear @Dey_Gautam discuss a question newly dear to my heart - how are nuclear properties tuned across species?
Stoked for the cytoplasm subgroup, kicked off by @MolinesArthur! Continues to blow my mind how anything at all can happen in the more crowded than a can of sardines cellular environment.
How about some highlights from #CellBio2022 ? @Stimac_V gave a FANTASTIC symposium talk this morning on her work with @Toliclab describing how spindle elongation helps pivot polar chromosomes and recover them from the “danger zone” of missegregation.
Speaking of postdocs - we’re hiring too! So if you’re a grad student close to finishing up and think it sounds fun to shoot lasers at cells (spoiler: it definitely is!!!) let’s talk!
He’s also on the job market - if you’re looking for a postdoc in the NYC/NJ/PHL area - reach out to him!
Looks like I’m once again doing that thing where I flake on Twitter until I come to a meeting. So, hi from #CellBio2022 👋
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