Chen Davidovich @DavidovichLab
Gene repression, RNA and all chromatin things. @MonashUni @EMBLAustralia davidovich-lab.com Melbourne, Australia Joined July 2017-
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Chen Davidovich retweeted
@vignesh_k757 Allosteric activation of PRC2 is coupled to adoption of the compact state. Our new bioRxiv manuscript shows that EZH2 S21-phos, adjacent to the SANT1 domain, restrains this conformational transition and limits activation. @vignesh_k757 & Ben Garcia lab tinyurl.com/4369kmh2
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Chen Davidovich retweeted
In the latest issue! RNA modifications in gene regulation: Functions and pathways dlvr.it/TRfPlf
Chen Davidovich retweeted
Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: academic.oup.com/nar/article/54… A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy! #nucleosomics #nucleosome #chromatin #cfDNA
Chen Davidovich retweeted
Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains dlvr.it/TRJ2mB
6/ A fantastic collaboration between the @DavidovichLab and the @Eddy_McGlinn labs, led by a brilliant PhD student, @SamAgius0, who is now looking for a postdoc position!
5/ We propose that H3K27me3 mimicry has repeatedly emerged during evolution as a mechanism to antagonise PRC2 and restrict the spread of Polycomb domains.
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. cell.com/molecular-cell…
Chen Davidovich retweeted
I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > nature.com/articles/s4159…
H3K79me2/3 is sufficient to antagonise PRC1 nature.com/articles/s4155…
Chen Davidovich retweeted
AlphaGenome paper and models are out today! nature.com/articles/s4158…. We have seen great community engagement since we released the API. We hope to open more use cases with the model weights! github.com/google-deepmin… We updated the supplementary note with some very interesting case studies. I encourage everyone using AlphaGenome for non-coding variant interpretation to read it. It was a huge team effort, I’m very proud of all of our co-authors @googledeepmind!
Chen Davidovich retweeted
Excited to share our latest preprint: "SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications" biorxiv.org/content/10.648… Led by @StefanProdic et al. #RNA #Epitranscriptomics #Nanopore 1/6
2/ Done in collaboration with the lab of @adrianbracken, who wrote a great 🧵 explaining the work. x.com/adrianbracken/…
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper surl.li/cgwqcq A thread 🧵
1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite: The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. embopress.org/doi/full/10.10…
Chen Davidovich retweeted
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper surl.li/cgwqcq A thread 🧵
Chen Davidovich retweeted
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on biorxiv.org/content/10.110…. Here's a thread with our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma
Chen Davidovich retweeted
Thrilled to see this out in @MolecularCell Led by the fantastic @sulteavn 👏 Revealing how PRC2 accessory proteins polymerise and shape gene regulation 🧬🌱 cell.com/molecular-cell…
Chen Davidovich retweeted
🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.110…
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Neil Blackledge
@blackledge_neil
333 Followers