Coller Lab @CollerLab
The Coller Lab uses modern approaches to investigate #quiescence, cell cycle control, #autophagy, and #cancer. Official account managed by the lab members. collerlab.dgsom.ucla.edu UCLA Joined November 2021-
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A nice follow-up to our recent @Nature paper (@BarbMarte). Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.” Very proud of the team. Interested to hear where these concepts go next. nature.com/articles/d4158…
Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? nature.com/articles/s4155… 1/10
Online today @ScienceMagazine Noncoding transcription controls the developmental dynamics of long-range gene regulation | Science science.org/doi/10.1126/sc…
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly
⭐️Check out the Perspective on cellular neighborhoods in cancer by @LichunMa, @KaiTanLab1 & co 🔗nature.com/articles/s4301… Part of our Series on Tumor Heterogeneity and Plasticity: nature.com/collections/gf…
Check out the latest from @Rachel_E_Savage, @JD_Buenrostro and many collaborators as part of the @IGVFConsortium
It takes two (transcription factors) to tango Transcription factor collaboration enables precise T cell state engineering tinyurl.com/tcelltfs Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium 🧵
⭐️Don't miss this Review published @NatureCancer as part of our Series on Tumor Heterogeneity and Plasticity 'Heterogeneity and plasticity of cancer-associated fibroblasts' ✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors 🔗nature.com/articles/s4301…
(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 biorxiv.org/content/10.648… biorxiv.org/content/10.110…
We are excited to release a single-cell and spatial 3D epigenomic atlas of developing human basal ganglia and inhibitory neurons, part of our BICAN effort in collaboration with @lab_paredes @jernst98 @emukamel @CEpigenomics @bpasaniuc biorxiv.org/content/10.648…
Excited to share a recent publication from the lab. Daniel Benjamin & Jengmin Kang led the study of the allocation of resources to survival over reproduction in stem cells during aging. #EvolutionaryTradeOffs #SurvivorshipBias science.org/doi/10.1126/sc…
H4K20me3 and CTCF act reciprocally at TAD boundaries to regulate cell state transitions biorxiv.org/content/10.648… #biorxiv_cellbio
@biorxiv_cellbio New preprint from @CollerLab.
We are so happy that Michael Cheng, a former undergraduate researcher in the lab and now a bioinformatics graduate student at @UCLA , will be defending his thesis this week (Wednesday at 1 pm; in person and on zoom). All the best, Michael!
🆕🎧 New Podcast: The founding of PG is discussed in interviews with Drs. AW Cowley, Jr., B Joe, and HA Coller. These interviews were organized and conducted by @AkinolaTosinS. Listen at ow.ly/L0MQ50Xok2H. Read the article at ow.ly/Vrxx50Xok2G.
New @NatureGenet review from our NIH SenNet @sennetresearch OMICS WG co-led by @shenglilab We share practical considerations for identifying, characterizing & spatially mapping #CellularSenescence, plus computational #multiomics insights!! nature.com/articles/s4158…
Years ago we tried to model cancer-associated fibroblast (CAF) subtypes in vitro, but gave up because only the proliferative subtype survived culture (duh!). This study could change all that: Perturb-seq with CRISPRa of 1,836 TFs induces diverse fibroblast states in vitro(!). 👏
Fantastic work by @thenormanlab in @NatureGenet Recreating fibroblast diversity in vitro by activating transcription factors Demonstration of the power of CRISPRa Perturb-Seq to deregulate TF expression in fibroblasts (Function!) nature.com/articles/s4158… nature.com/articles/s4158…
A new bridge recombination edit just dropped! 👀
Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing
Dr. Hilary Coller (@CollerLab) discussed her latest research on how epigenetic patterns can predict cancer outcomes more accurately than traditional markers. Her pan-cancer model reveals targetable epifactors across five tumor types. Watch the talk here: bit.ly/4jEAMTU
Join us for our next seminar with Dr. Hilary Coller of @UCLA! ➡️ youtube.com/watch?v=3bh0M9…
Less than one month away from abstract submission deadline for the 2025 GRC/GRS Genome Architecture meeting at the beautiful beach in California. Don't miss it!
Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration deadline: Mar 18, 2025. grc.org/genome-archite…
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