Clinical Pharmacology & Analytical Chemistry Lab @CPACLab
The CPAC Lab, led by Angela Kashuba, former dean of @UNCPharmacy, supports the global #HIV research community through expertise in pharmacology med.unc.edu/cfar/core-area… Joined April 2020-
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📈 Image Fusion Restores Spatial Resolution Following Pixel‑Based Signal Averaging in Orbitrap MSI, Abstract# 328103, presented by Yury Desyaterik, Thursday June 4
📈 Development and Validation of an LC-MS/MS Method for Quantification of Protein-Unbound Doravirine in Human Plasma using Rapid Equilibrium Dialysis, Abstract# 327669, presented by Amanda Schauer, Monday June 1
We're headed to ASMS 2026, hope to see you there! Register 👉 asms.org/conferences/an… Abstract details below!
Our recent work was featured as a Clinical Research Update in HIV Specialist Magazine!! 💊 Engel N, et al. Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention. J Infect Dis. 2026 Feb 18;233(2):257-260. onlinedigeditions.com/publication/?i…
We supported 7 abstracts at CROI 2026!! Nathan Engel and Amanda Poliseno had great poster presentations, and our team posed with the Blue Blear in Denver, Colorado 😀
New @JIDJournal editorial favors pursuit of a clinical trial assessing on-demand #PrEP in women following our model-informed predictions of its efficacy for #HIVprevention 🔗 Editorial: academic.oup.com/jid/advance-ar… 🔗 Original Publication: academic.oup.com/jid/advance-ar…
CPAC Lab holiday fun!!
Our research advocating for 2-1-1-1 on-demand PrEP for cisgender women was featured in @BodyPROHIV! Check out Mackenzie Cottrell's interview with commentary from Jenell Stewart @HennepinHC discussing this "exciting step in the right direction" 🔗thebodypro.com/hiv/on-demand-…
New from our lab! Adding a 4th day to the on-demand PrEP regimen may boost HIV protection for cisgender women, according to new modeling research. academic.oup.com/jid/advance-ar… #HIVPrevention #PrEP #WomensHealth #UNCPharmacy
🎉 Happy to share that Eli Rosen was awarded an R01! This collaboration with OHSU will benchmark PK for both long-acting and daily ARVs in rhesus macaques and examine how pre-treatment immunopathogenic damage affects ARV tissue penetration reporter.nih.gov/search/xxd0xcu… #HIVResearch
Our collaboration with University of Colorado compares direct vs. indirect DBS assays for HIV PrEP adherence. We offer guidance for clinical interpretation, including adjustments for sample degradation outside cold-chain. 🔗 doi.org/10.1093/jac/dk… #HIVPrevention #PrEP
Antiretrovirals don’t reach all genital tissues equally—some areas may be underprotected. New imaging from a collaboration with our laboratory reveals why this matters for prevention and cure. #HIVresearch #ARVs #HIVprevention …ncbi-nlm-nih-gov.libproxy.lib.unc.edu/40323085/
New guidelines from a collaboration with our laboratory improve how we read PrEP drug levels in blood spots—helping ensure people get the protection they need. #HIVprevention #PrEP #Adherence …ncbi-nlm-nih-gov.libproxy.lib.unc.edu/40536250/
The HIV PDR is revolutionizing how HIV drug data is shared—making decades of research searchable, standardized, and ready to power the next breakthroughs in treatment and prevention. #HIVresearch #DataSharing Check out our publication here 👉 doi-org.libproxy.lib.unc.edu/10.1002/cpt.36…
#CROI2025 was fantastic! We are incredibly proud of Mackenzie Cottrell and her well-received oral presentation, "Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention", which is featured on NATAP! natap.org/2025/CROI/croi…
Check out our upcoming abstract presentation when you're at #ASCPT2025!! A Modeling Approach to Expedite the Development of a New Long-Acting Controlled-Release Multipurpose Formulation Containing Medroxyprogesterone Acetate
📊Long-Acting Injectable CAB/MPA MPT Implant for Prevention of HIV and Unintended Pregnancy
📊Dose-Ranging Pharmacokinetics and Efficacy of a 90-Day Multipurpose IVR Delivering Islatravir 📊Effect of Antiretroviral Regimen on Contraceptive Failure Among Women Using Injectable Contraception
We are authors on 8 abstracts at #CROI2025!! Titles for 3 oral 🎙️ and 5 poster 📊 presentations are below
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